Significant anti-inflammatory and anti-arthritic activities were observed in animals treated with β-lap. The effects of β-lap can be attributed in part to immunomodulation with reduction of pro-inflammatory cytokines and NO.

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Although dating applications (apps) have become popular among young adults, there is a dearth of information regarding the sexual health implications among Brazilian college students. This study examined risky sexual behavior and attitudes of dating app users, based on their sex in Brazil’s Legal Amazon. Three hundred and fifty-nine students reported their sociodemographic data, dating app use, and sexual behaviors and attitudes through self-administered questionnaires. Bivariate analyses and analysis of variance (ANOVA) with Bonferroni post-hoc tests were performed. Dating app use was reported by 238 (66.3%) subjects, most of whom had an encounter and sex with a casual partner. Women frequently requested condom use. Trust in one’s partner or having repeated encounters were the main reasons for engaging in risky sexual behavior. Men had a greater number of sexual partners and less protective attitudes. Sexual health awareness by apps was not reported by 97% of women, and most of them were not tested for sexually transmitted infections. A positive attitude toward sexual health was not a predictor of safe sex. Important similarities and differences regarding risky sexual behaviors and attitudes were observed between the sexes, many of which correlated with increased sexual vulnerability during the sexual encounters arranged through the dating apps. This cross-sectional study supports efforts on sexual health promotion and sexual education implementation in the face of growing usage of apps among young adults for sexual matters.

| Background: Metabolic syndrome and chronic diseases have impact on the job performance of police officers. Objective: To investigate the association of overweight/obesity and cardiovascular risk factors with work shift and duration of employment among police officers. Methods: Cross-sectional study with 102 police officers in Cajazeiras, Paraíba, Brazil, in which we analyzed sociodemographic data, occupational characteristics, body mass index (BMI), lipid profile, personal history of disease and lifestyle. Statistical analysis included the chi-square and Fisher’s exact test. Results: Overweight/obesity was found among most participants (83.3%). Hypertriglyceridemia (49.1%), low HDL-C (56.9%) and high LDL-C (46.1%) levels were associated with abnormal BMI (p<0.05). Hypertension was the main disease reported by overweight/obese participants (28.2%) (p=0.01). Job position, lifestyle and work shift were not associated with any of the analyzed variables, however, abnormal BMI, dyslipidemia, and hypertension were frequent among the participants with 6-10 or more than 10 years in the job (p<0.05). Conclusion: Part of the participants with at least 6 years in the job exhibited overweight/obesity in association with dyslipidemia and hypertension. We recommend prevention and therapeutic strategies to protect officers from chronic diseases or attenuate their long-term complications. Additional prospective studies are needed to confirm the associations we found, mainly between duration of employment and occupational diseases.

This study investigates the impact of social isolation, weight changes, and physical activity (PA) by the electronic tools (eTools) on the quality of life (QoL) of Brazilian medical students during the COVID-19 pandemic. Methods:In this observational longitudinal study, one hundred eighty-nine medical students completed an e-questionnaire, which used the WHOQOL-Bref instrument to report QoL and sociodemographic characteristics, health conditions, and lifestyles related to PA. Cronbach's alpha and Friedman/Dunn and Spearman's correlation tests were performed. Based on descriptive and inferential statistics, a multiple linear regression was used to evaluate the potential predictors of QoL. Results: The COVID-19 pandemic particularly affected the psychological and social domains.Time spent indoors and a non-ideal BMI had a negative impact on QoL. Being female and sexual minority-group membership were associated with lower QoL scores in the psychological and physical domains, respectively. Access to PA eTools was positively associated with QoL. Being monitored by a physical education teacher contributes to satisfactory PA levels during online classes. Conclusion: This study provides novel insights into the access of PA eTools on QoL during the COVID-19 pandemic. During periods of social distancing, people should pay extra attention to self-care strategies to protect mental health and promote positive lifestyle patterns. In addition, using online PA resources monitored by physical education teachers could be a strategy to maintain satisfactory levels of exercise.

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Novel strategies for the prevention and treatment of sepsis-associated acute kidney injury and its long-term outcomes have been required and remain a challenge in critical care medicine. Therapeutic strategies using lipid mediators, such as aspirin-triggered resolvin D1 (ATRvD1), can contribute to the resolution of acute and chronic inflammation. In this study, we examined the potential effect of ATRvD1 on long-term kidney dysfunction after severe sepsis. Fifteen days after cecal ligation and puncture (CLP), sepsis-surviving BALB/c mice were subjected to a tubulointerstitial injury through intraperitoneal injections of bovine serum albumin (BSA) for 7 days, called the subclinical acute kidney injury (subAKI) animal model. ATRvD1 treatment was performed right before BSA injections. On day 22 after CLP, the urinary protein/creatinine ratio (UPC), histologic parameters, fibrosis, cellular infiltration, apoptosis, inflammatory markers levels, and mRNA expression were determined. ATRvD1 treatment mitigated tubulointerstitial injury by reducing proteinuria excretion, the UPC ratio, the glomerular cell number, and extracellular matrix deposition. Pro-fibrotic markers, such as transforming growth factor β (TGFβ), type 3 collagen, and metalloproteinase (MMP)-3 and -9 were reduced after ATRvD1 administration. Post-septic mice treated with ATRvD1 were protected from the recruitment of IBA1+ cells. The interleukin-1β (IL-1β) levels were increased in the subAKI animal model, being attenuated by ATRvD1. Tumor necrosis factor-α (TNF-α), IL-10, and IL-4 mRNA expression were increased in the kidney of BSA-challenged post-septic mice, and it was also reduced after ATRvD1. These results suggest that ATRvD1 protects the kidney against a second insult such as BSA-induced tubulointerstitial injury and fibrosis by suppressing inflammatory and pro-fibrotic mediators in renal dysfunction after sepsis.