Objective. Ovarian
carcinomas are presumed to arise within ovarian
inclusion cysts or from a coexisting epithelial
lesion in the ovary. Insight may be gained by
relating different subtypes of ovarian cancer
with the presence of coexisting tumor-like
conditions. Methods. The Dutch
nation-wide pathology database PALGA
(Pathologisch Anatomisch Landelijk
Geautomatiseerd Archief) identified the various
histopathological subtypes of ovarian cancer in
824 patients diagnosed in 1996–2003, and
recorded the presence of epithelial tumor
conditions around the ovarian tumors. In
addition, a PALGA database of all 153 consecutive
patients referred to the Nijmegen University
Medical Centre in 2007 for histopathological
work-up was analyzed. Results.
The prevalence of coexisting ovarian tumor
conditions was 16.4% (135 out of 824
patients,
(95% CI: 8.4%–24.4%)). The coexistence was highest for
endometrioid, mucinous, clear cell, and
borderline malignancies. The referral group
revealed 35% (54 out of 153 patients,
(95% CI: 28%–42%))
of coexisting epithelial ovarian tumor
conditions. Conclusion. One in
six patients with a malignant ovarian tumor has
a coexisting epithelial tumor condition in the
ovary, which is also rather frequently observed
in the diagnostic work-up
practice.
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