A method to control activation of a DNA nanodevice by supplying a complementary\ud DNA (cDNA) strand from an electro-responsive nanoplatform is reported. To develop\ud functional nanoplatform, hexalayer nanofilm is precisely designed by layer-by-layer\ud assembly technique based on electrostatic interaction with four kinds of materials:\ud Hydrolyzed poly(β-amino ester) can help cDNA release from the film. A cDNA is\ud used as a key building block to activate DNA nanodevice. Reduced graphene oxides\ud (rGOs) and the conductive polymer provide conductivity. In particular, rGOs efficiently\ud incorporate a cDNA in the film via several interactions and act as a barrier. Depending\ud on the types of applied electronic stimuli (reductive and oxidative potentials), a\ud cDNA released from the electrode can quantitatively control the activation of DNA\ud nanodevice. From this report, a new system is successfully demonstrated to precisely\ud control DNA release on demand. By applying more advanced form of DNA-based\ud nanodevices into multilayer system, the electro-responsive nanoplatform will expand\ud the availability of DNA nanotechnology allowing its improved application in areas\ud such as diagnosis, biosensing, bioimaging, and drug delivery

No abstract

Phlorofucofuroeckol-A (PFF-A) is a phlorotannin extracted from various brown algae. PFF-A shows low toxicity when ingested and various biochemical effects, including antioxidant, anti-inflammatory, anti-cancer, and anti-allergy properties. In this study, various di-O-substituted PFF-A derivatives were synthesized by introducing alkyl or acyl groups at two specific hydroxyls out of the nine nearly equivalent phenolic OH groups present in PFF-A. The exact molecular structures of the synthesized derivatives were analyzed using two-dimensional nuclear magnetic resonance (2D NMR) spectroscopy, which confirmed that the substituents were regioselectively introduced at the 1 OH and 6 OH positions. Small amounts of three mono-O-substituted derivatives were generated as by-products in this reaction, and their structures and regioselectivity were determined using 2D NMR spectroscopy. This study can provide insights into understanding the mechanism of action of eckol-based compounds and developing new drug candidates.

No abstract

A nonconventional strategy in DNA nanodevice activation is determined by F. Ricci, J. Hong, and co‐workers on page 5572, using a graphene and DNA based electro‐responsive multilayer nanofilm by means of layer‐by‐layer assembly. The nanofilm onto a chip‐electrode controls spontaneous conformational change of the DNA nanodevice via controlled release of complementary strands as a trigger, depending on electronic inputs including reductive potentials that allow efficient activation of a DNA nanodevice.