Alveolar bone regeneration is a significant challenge in dental implantation. Novel biomaterials and tissue-engineered constructs are under extensive development and awaiting in vivo animal tests to find clinical endpoint. Here, we establish a novel in vivo model, modifying gingivoperiosteoplasty in rat for the alveolar bone regeneration. Rat premaxillary bone defects were filled with silk scaffold or remained empty during the implantation period (up to 6 weeks), and harvested samples were analyzed by micro-computed tomography and histopathology. Empty defects showed increased but limited new bone formation with increasing implantation period. In defects implanted with silk sponge, the bone formation was significantly greater than that of empty defect, indicating an effective role of silk scaffold in the defect model. The modified premaxillary defect model in rat is simple to perform, while mimicking the clinical conditions, finding usefulness for the development of biomaterials and tissue-engineered constructs targeting alveolar bone regeneration in dental implantation.

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In this paper, the design of DSC-PLL (Delayed Signal Cancellation Phase Locked Loop) based on FPGA is discussed. This method shows outstanding performance for detection of fundamental positive sequence component voltage when the grid voltage is polluted by grid harmonics and voltage unbalance. The harmonic elimination technique of DSC is analyzed and DSC-PLL method is implemented on FPGA with a discrete fixed point based. Process for FPGA design is investigated and DSC-PLL is designed by system generator compatible with MATLAB/SIMULINK, by which schematic is directly converted to HDL (Hardware Descriptions Language) and then programmed into the FPGA. To verify the performance of the FPGA based DSC-PLL and conventional SRF-PLL, two methods are implemented on XC7Z030 and are tested under distorted three-phase voltage conditions respectively. The results show the SRF-PLL contains continuous oscillations with harmonic influence, but the proposed FPGA based DSC-PLL perfectly eliminates any harmonics within maximum 5.44ms and detects the fundamental positive sequence successfully under distorted three-phase voltage.I.

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