Rechargeable metal-air batteries have attracted a great interest in recent years because of their high energy density. The critical challenges facing these technologies include the sluggish kinetics of the oxygen reduction-evolution reactions on a cathode (air electrode). Here, we report doped lanthanum nickelates (La2NiO4) with a layered perovskite structure that serve as efficient bifunctional electrocatalysts for oxygen reduction and evolution in an aqueous alkaline electrolyte. Rechargeable lithium-air and zinc-air batteries assembled with these catalysts exhibit remarkably reduced discharge-charge voltage gaps (improved round-trip efficiency) as well as high stability during cycling.

Electrical discharge machining (EDM) is one of the most extensively used non-conventional material removal processes. The Taguchi method has been utilized to determine the optimal EDM conditions in several industrial fields. The method, however, was designed to optimize only a single performance characteristic. To remove that limitation, the Grey relational analysis theory has been used to resolve the complicated interrelationships among the multiple performance characteristics. In the present study, we attempted to find the optimal machining conditions under which the micro-hole can be formed to a minimum diameter and a maximum aspect ratio. The Taguchi method was used to determine the relations between machining parameters and process characteristics. It was found that electrode wear and the entrance and exit clearances had a significant effect on the diameter of the micro-hole when the diameter of the electrode was identical. Grey relational analysis was used to determine the optimal machining parameters, among which the input voltage and the capacitance were found to be the most significant. The obtained optimal machining conditions were an input voltage of 60V, a capacitance of 680pF, a resistance of 500Ω, the feed rate of 1.5µm/s and a spindle speed of 1500rpm. Under these conditions, a micro-hole of 40µm average diameter and 10 aspect ratio could be machined.

BackgroundIn type 2 diabetes mellitus, fixed-dose combination (FDC) can provide the complementary benefits of correction of multiple pathophysiologic defects such as dysfunctions in glycemic or metabolic control while improving compliance compared with separate tablets taken together. The objective of the study reported here was to compare the pharmacodynamic (PD), pharmacokinetic (PK), and tolerability profiles of gemigliptin and extended-release metformin (metformin XR) between FDC and separate tablets.MethodsA randomized, open-label, single-dose, two-way, two-period, crossover study was conducted in 28 healthy male volunteers. Two FDC tablets of gemigliptin/metformin 25/500 mg or separate tablets of gemigliptin (50 mg ×1) and metformin XR (500 mg ×2) were orally administered in each period. Serial blood samples were collected up to 48 hours post-dose to determine dipeptidyl peptidase 4 (DPP-4) activity using spectrophotometric assay and concentrations of gemigliptin and metformin using tandem mass spectrometry. Geometric mean ratios (GMRs) of FDC to separate tablet formulations and their 90% confidence intervals (CIs) were calculated to compare the PD and PK parameters between the two formulations. Tolerability was assessed throughout the study.ResultsThe plasma DPP-4 activity–time curves of the FDC and the separate tablets almost overlapped, leading to a GMR (90% CI) of the FDC to separate tablets for the plasma DPP-4 activity and its maximum inhibition of 1.00 (0.97–1.04) and 0.92 (0.82–1.05), respectively. Likewise, all of the GMRs (90% CIs) of FDC to separate tablets for the area under the plasma concentration–time curve and maximum plasma concentration of gemigliptin and metformin fell entirely within the conventional bioequivalence range of 0.80–1.25. Both the FDC and separate tablets were well tolerated.ConclusionThe PD, PK, and tolerability profiles of gemigliptin and metformin XR in FDC and separate tablets were found to be comparable. The FDC tablet of gemigliptin and metformin sustained release can be a convenient therapeutic option in patients with type 2 diabetes mellitus requiring a combination approach.

Gemigliptin does not affect the PK properties of rosuvastatin or irbesartan; also, rosuvastatin and irbesartan do not affect the PKs of gemigliptin.

Coronary air embolism remains a serious complication of coronary catheterization despite performing careful procedure to prevent this. We report here on a case of massive coronary air embolism that was complicated by cardiogenic shock in a 52-year-old male patient with angina pectoris. The patient had a stenosis in the middle left anterior descending artery (LAD) and percutaneous coronary intervention (PCI) was planned for the LAD lesion. During PCI, inadvertent manipulation of a pressure line induced massive air embolism in both proximal left coronary arteries, and this manifested as cardiogenic shock. The patient recovered after supportive measures and successive intracoronary injections of nitroglycerin and then he eventually underwent successful PCI.

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Everyday in Korea, more than hundred thousands of News articles and postings are generated by either writers or users. Many people read News articles and write their opinions on the articles through major News portal systems such as Naver or Daum. However, they are sometimes time-consuming, biased, and distracted by unnecessary information. We propose a realtime News recommendation system called PADAC^2, that is more passive process for users to browse their interests from massive News media. We propose a recommendation algorithm called HeteRoCommender based on heterogeneous source of social footprints given.