Background: Cannabidiol (CBD) is considered a promising neuroprotectant after perinatal hypoxia-ischemia (HI). We have previously studied the effects of CBD 1 mg/kg in the early phase after global HI in piglets. In contrast to prior studies, we found no evidence of neuroprotection and hypothesized that higher doses might be required to demonstrate efficacy in this animal model. Objective: To assess the safety and potential neuroprotective effects of high-dose CBD. Methods: Anesthetized newborn piglets underwent global HI by ventilation with 8% O2 until the point of severe metabolic acidosis (base excess -20 mmol/L) and/or hypotension (mean arterial blood pressure ≤20 mm Hg). Piglets were randomized to intravenous treatment with vehicle (n = 9) or CBD (n = 13). The starting dose, CBD 50 mg/kg, was reduced if adverse effects occurred. The piglets were euthanized 9.5 h after HI and tissue was collected for analysis. Results: CBD 50 mg/kg (n = 4) induced significant hypotension in 2 out of 4 piglets, and 1 out of 4 piglets suffered a fatal cardiac arrest. CBD 25 mg/kg (n = 4) induced significant hypotension in 1 out of 4 piglets, while 10 mg/kg (n = 5) was well tolerated. A significant negative correlation between the plasma concentration of CBD and hypotension during drug infusion was observed (p < 0.005). Neuroprotective effects were evaluated in piglets that did not display significant hypotension (n = 9) and CBD did not alter the degree of neuronal damage as measured by a neuropathology score, levels of the astrocytic marker S100B in CSF, magnetic resonance spectroscopy markers (Lac/NAA and Glu/NAA ratios), or plasma troponin T. Conclusions: High-dose CBD can induce severe hypotension and did not offer neuroprotection in the early phase after global HI in piglets.
Tidligere overlege Ruth Bostad fra Oslo døde 20. mai 2017. Hun ble 84 år gammel. Ruth tok sin medisinske embetseksamen i 1957 og ble spesialist i barnesykdommer i 1966. I hele sitt yrkesaktive liv arbeidet hun med nevrologiske sykdommer hos barn og med habilitering, og ble en av nestorene innenfor norsk barnenevrologi. Som overlege ved Barneklinikken på Rikshospitalet og Sentralinstituttet for habilitering (Berg gård) opparbeidet hun seg en betydelig kunnskap og erfaring og var faglig høyt ansett blant kolleger, også utenfor medisinen. Vi som arbeidet sammen med henne, opplevde henne som engasjert, kunnskapsrik og alltid imøtekommende og villig til å laere fra seg. Hun var en utmerket laerer, noe som flere av oss hadde glede av. I tillegg var hun en eminent kliniker med saerdeles god observasjonsevne, og et godt medmenneske med stor empati. Ruths interesse og omsorg for pasientene betydde svaert mye for barna og deres foreldre. De opplevde henne som omsorgsfull, støttende og tillitsskapende. Det er viktige egenskaper hos en barnelege.Ruth hadde brede interesser, men barn med cerebral parese, barn med ryggmargsbrokk og barn med progredierende nevrologiske sykdommer sto henne saerlig naer. Hun var spesielt
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