Multiple sclerosis in children and adolescents. An important differential diagnosis of acute neurological disease

Sandvig, Inger; Barlinn, Jon; Nedregaard, Bård; Skjeldal, Ola H.

doi:10.1016/j.ejpn.2014.12.004

Cited by 7 publications

(6 citation statements)

References 19 publications

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“…Finally, known group validity of the PFS was supported, in that those individuals with chronic conditions reported higher levels of physical and mental fatigability than individuals in the health adults group. This finding is consistent with research that has supports that persons with chronic conditions exhibit high levels of fatigability (Dobkin, 2008; Finsterer and Mahjoub, 2014; Kluger et al, 2013; Sandvig et al, 2015). Taken together, while findings are generally favorable and support the validity of the PFS, it is likely that the items that are exhibiting poor reliability are likely having a negative impact on the psychometric validity of the scale.…”

Section: Discussionsupporting

confidence: 92%

“…Second, known group validity was only examined for the Physical Fatigability score. In addition, prior development work has focused solely on older adults with no psychometric data to support or refute the clinical utility of this measure in chronic conditions where high levels of fatigability are common (Dobkin, 2008; Finsterer and Mahjoub, 2014; Kluger et al, 2013; Sandvig et al, 2015). Moreover, published data regarding the PFS in independent samples (i.e.…”

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confidence: 99%

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Validation of the Pittsburgh Fatigability Scale in a mixed sample of adults with and without chronic conditions

et al. 2019

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The aim of this study was to validate the Pittsburgh Fatigability Scale in three different groups: adults with multiple sclerosis ( n = 65), fibromyalgia ( n = 64), and healthy adults ( n = 86). Participants completed the Pittsburgh Fatigability Scale and other self-report measures. While findings supported the internal consistency of the Pittsburgh Fatigability Scale (all Cronbach’s alpha ⩾ 0.85), standard error of measurement estimates were larger than hypothesized. In addition, while item-level reliability was generally supported, item-total correlations for two items were lower than expected. Convergent and discriminant validity were supported, and the Pittsburgh Fatigability Scale was able to distinguish between individuals with and without chronic disease. Overall, the Pittsburgh Fatigability Scale exhibited acceptable psychometric properties.

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Section: Discussionsupporting

confidence: 92%

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confidence: 99%

Validation of the Pittsburgh Fatigability Scale in a mixed sample of adults with and without chronic conditions

et al. 2019

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“…40 Three studies in our review (2 from Italy and 1 from the United States) reported the FSS on this scale, with means ranging from 27.1 to 30.06. [41][42][43] Four studies reported on fatigue using the percentage of patients self-reporting fatigue (range, 23%-61.1%) [44][45][46][47] with 1 study from Canada finding a larger proportion of patients with POMS reporting chronic fatigue (43.8% vs 0.0%) compared with age-matched healthy controls. 47 One study reported on fatigue using the Modified Fatigue Impact Scale, presenting a mean of 32.52 among patients with POMS compared with 23.10 among ageand sex-matched healthy controls.…”

Section: Quality Of Lifementioning

confidence: 99%

The Economic and Humanistic Burden of Pediatric-Onset Multiple Sclerosis

Greene

Araujo

Campos

et al. 2022

Journal of Health Economics and Outcomes Research

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Background: Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the central nervous system. Pediatric-onset MS (POMS), defined as onset of MS before 18 years of age, is estimated to account for 2% to 5% of the MS population worldwide. Objectives: To conduct a literature review focused on the healthcare resource utilization and cost as well as quality-of-life (QOL) outcomes among patients with POMS. Methods: We conducted a systematic literature review of English-language studies published after September 2010 in MEDLINE and Embase to describe the global economic healthcare resource utilization and costs and humanistic (QOL) burden in patients with POMS. Results: We found 11 studies that reported on healthcare resource utilization, cost, or insurance coverage and 36 studies that reported on QOL outcomes in patients with POMS. Patients with POMS had higher rates of primary care visits (1.41 [1.29-1.54]), hospital visits (10.74 [8.95-12.90]), and admissions (rate ratio, 4.27 [2.92-6.25];OR, 15.2 [12.0-19.1]) compared with healthy controls. Mean per-patient costs in the United States were $5907 across all settings per year of follow-up between 2002 and 2012; mean costs per hospital stay were $38 543 (in 2015 USD) between 2004 and 2013. Three studies reported psychosocial scores between 71.59 and 79.7, and 8 studies reported physical health scores between 74.62 to 82.75 using the Pediatric Quality of Life Measurement Model (PedsQLTM). Twelve studies used the PedsQL™ Multidimensional Fatigue Scale. Mean scores on the self-reported general fatigue scale ranged from 63.15 to 78.5. Quality-of-life scores were lower than those of healthy controls. Discussion: Our review presents a uniquely broad and recent overview of the global economic and humanistic burden of patients with POMS. Additional research on healthcare resource utilization and cost would provide a more robust understanding of the economic burden in this population. Conclusions: Healthcare resource utilization and costs are high in this population, and patients report reduced QOL and significant fatigue compared with healthy children and adolescents.

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“…1,2 Apesar do diagnóstico ser geralmente realizado na idade adulta, os sintomas surgem antes dos 18 anos em até cerca de 10% dos indivíduos. 1,3,4 A aplicabilidade dos critérios de McDonald no diagnóstico de EM em crianças com idade igual ou superior a 11 anos já se encontra estabelecida desde a sua revisão em 2010. 5 Na revisão de 2017, as lesões sintomáticas foram incluídas para demonstrar disseminação no tempo (DT) e no espaço (DE), assim como a síntese intratecal de bandas oligoclonais (BOCs) passou a representar um critério para DT e as lesões corticais um critério para DE.…”

Section: Introductionunclassified

Multiple Sclerosis Diagnosis in Adolescents by 2017 McDonald Criteria: Two Case Reports

Araújo¹

2024

Sinapse

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Multiple Sclerosis Diagnosis in Adolescents by 2017 McDonald Criteria: Two Case Reports ResumoApesar do diagnóstico de esclerose múltipla (EM) ser geralmente realizado em idade adulta, a apresentação ocorre antes dos 18 anos em até 10% dos indivíduos. Desde a revisão de 2010 dos critérios de McDonald, que estes podem ser aplicados no diagnóstico de EM em adolescentes. Apresentamos dois casos de diagnóstico nesta faixa etária: o primeiro de uma adolescente com antecedentes familiares de EM com apresentação de nevrite ótica retrobulbar à direita e lesões da substância branca periventriculares e infratentoriais; e o segundo de um adolescente com uma apresentação sugestiva de mielite aguda transversa, com nível sensitivo em D10, e múltiplas lesões inflamatórias cerebrais e medulares. A pesquisa de bandas oligoclonais no líquido cefalorraquidiano foi positiva em ambos. Ambos cumpriam os critérios de McDonald de 2017 para diagnóstico de EM. O diagnóstico de EM em idade pediátrica é complexo, necessitando de um alto grau de suspeição. A ponderação de outros diagnósticos, especialmente outras doenças cerebrais de natureza inflamatória, é imprescindível.

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Multiple sclerosis in children and adolescents. An important differential diagnosis of acute neurological disease

Cited by 7 publications

References 19 publications

Validation of the Pittsburgh Fatigability Scale in a mixed sample of adults with and without chronic conditions

Validation of the Pittsburgh Fatigability Scale in a mixed sample of adults with and without chronic conditions

The Economic and Humanistic Burden of Pediatric-Onset Multiple Sclerosis

Multiple Sclerosis Diagnosis in Adolescents by 2017 McDonald Criteria: Two Case Reports

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