Abstrak-Penyakit jantung koroner (PJK) terutama disebabkan oleh aterosklerosis karena hiperkolesterolimia. Oksidasi low density lipoprotein (LDL) oleh reactive oxygen species (ROS) sebagai penyebab utama proses aterogenik dapat dicegah dengan kehadiran antioksidan seperti vitamin E. Buah dan sayuran banyak mengandung vitamin. Salah satu buah yang mengandung vitamin E adalah buah merah (Pandanus conoideus Lam.). Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak buah merah terhadap kadar LDL darah pada tikus putih (Rattus norvegicus L.). Jenis penelitian ini adalah penelitian eksperimental laboratorium yang didesain mengikuti Rancangan Acak Lengkap (RAL) dengan 6 perlakuan dan 4 kali ulangan dengan parameter penelitian adalah kadar LDL darah tikus putih. Data dianalisis menggunakan one way anova dilanjutkan dengan uji Duncan 95%. Berdasarkan hasil penelitian, minyak buah merah memiliki kemampuan untuk menurunkan kadar LDL darah tikus putih.Kata Kunci: minyak buah merah, aterosklerosis, LDL.

Abstract- 157,62 ± 17,54; 341,55 ± 12,73; 196 ± 16,32; 196,17 ± 16,93 mg/dL.

Student learning outcomes are competencies that students have after gaining their learning experience, so indicators of learning success can be seen from student learning outcomes after experiencing the learning process. Student learning outcomes can be improved through the use of learning models, one of which is by applying the POE learning model (Prediction, Observation and Explanation) with probing-prompting techniques. The purpose of this study was to determine the effect of POE learning models (Prediction, Observation and Explanation) with probing-prompting techniques on the cognitive learning outcomes of the tenth grade students at SMA Muhammadiyah 3 Jember on the environmental pollution subject. Type of research is a quasy experimental study using a pretest and posttest design. In the experimental class, learning activity was carried out by applying the POE learning model (Prediction, Observation and Explanation) with probing-prompting techniques and the control class, learning activities are carried out by applying conventional learning models. The data of the students' cognitive learning outcomes were obtained through the pretest and posttest scores then analyzed using ANAKOVA test. The application of POE learning model (Prediction, Observation and Explanation) with probing-prompting techniques had a significant effect with a probability as much as 0,000. The affective learning outcomes influenced significantly with a significance value of 0.001 or p<0.05.

This study aims to develop textbooks on Brain-Based Learning in Materials Organization of Life for the Junior High School. 92.8% of 70 students from Tenth Junior High School said need an interesting picture book, 92.8% of 70 students require illustrative images that support the material, and 89.9% said need a book that helps remember long-term. The purpose of this study is to obtain a development process and textbook based on Brain-Based Learning (BBL) that Effectiveness for The Students Junior High School in science learning. Method tools are using mneumonic, comic strips, songs and images. This research was conducted in MTs Nurul Huda Banyuwangi with research subjects of class VII A in the academic year 2019/2020. The type of this research is (research and development), using 4-D model Thiagarajan, but only used 3 stages define, design, and develop. The technique of collecting data is by collecting test methods, teachers’ interview, questionnaire for teachers and students, and observation. The data analysis technique consists of effectiveness analysis by using N-gain and learning retention. The results shows that 31 students experienced an increase in learning outcomes from the low to the good category. Effectiveness can be seen from the difference in the pre-test and post-test in the N-gain test with 0.77 which indicates a high category. Retention results were obtained based on analysis of learning retention at 93.25 with a high category.

Pheretima sp is an earthworm from the Oligochaeta group found mostly in Java. The characteristics has segments reaching 95-150 segments. Clitellum is located in segment 14-16. The body fluids contain protein, amino acids and various enzymes. The purpose of this study was to determine the composition of bioactive compounds and evaluate antibacterial activity. The method used was maceration, antibacterial test against Salmonella typhi and GCMS analysis to identify bioactive compounds. Antibacterial test showed the inhibition zone diameter ranged from 15 to 20 mm. The identification of bioactive compounds is based on the percentage area, percentage peak height, retention time, molecular weight and pharmacological action. GC-MS analysis showed the presence of 50 peaks of compounds. Bioactive compounds which are antibacterial are 1) Nitrogen oxide (N2O) (CAS) Nitrous oxide with an area 2.03%, height 7.36%, retention time 1.361, molecular weight 44.013 g/mol; 2) Acetic acid (CAS) Ethylic acid with an area 17.02%, height 29.03%, retention time 1.789, and molecular weight 60.05 g/mol; 3) Butanoic acid, 3-methyl-(CAS) Isovaleric acid with an area of 3.27%, height 2.04%, 3.456, molecular weight 102.13 g/mol; 4) 1,2-Benzenedicarboxylic acid, diethyl ester (CAS) with an area 0.95%, height 1.32%, retention time 36.306 and molecular weight 222.24 g/mol.

Nervous system material is very complicated to learn so it needs thinking skills to develop understanding and improve cognitive performance that is using metacognitive skills. The purpose of this study is to analyze the metacognitive skills of junior high school students on regulation system material with different academic abilities. This research is a qualitative descriptive study. The research method uses a mix method (qualitative and quantitative). Qualitative data in the form of descriptive based on observations. Quantitative data are in the form of the MAI (Metacognitive Awareness Inventory) test based on MAI indicators, namely Knowledge About Cognition and Regulation of Cognition. This study into 3 categories, namely students with high, medium and low academic abilities. The results of the metacognitive research with high academics obtained an average value of 59.45, metacognitive with moderate academics obtained an average value of 60.44 and metacognitive with low academics obtained an average value of 59.45

 Abstract: Typhoid fever is systemic infectious disease caused by Salmonella typhi bacteria which is still considered as a health problem for the world people. This reasearch aims to know the healing efffects of fresh earthworm species Pheretima javanica to reduction typhoid fever replace the treatment using cloramphenicol. This research using male white rats (Rattus norvegicus L.) with negative control and positive control by using cloramphenicol. and 4 treatments group of each 5 rats. The test consists of Widal test, feces test and body weight measurement were analyzed descriptively, while body temperature measurement was analyzed by using ANOVA test and continued with Duncantest with confidence rate at 95%. The analyzed result got probably result p = 0,0001 (p < 0,05) means that fresh earthworm has a significant effect on the reduction of typhoid fever on male white rats with optimal dosage is 3 gram / 0.2 kg BB.

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