The mental and physical disability associated with end-stage ankle arthrosis is at least as severe as that associated with end-stage hip arthrosis.

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These results indicate that rhPDGF is a safe product and provides clinical/radiographic outcomes that justify the pursuit of randomized controlled studies comparing rhPDGF/TCP to autograft.

Most respondents preferred using the AOFAS Ankle score. The use of the empirical AOFAS Ankle score continues among AOFAS members.

The COFAS classification system appears to be a valid tool for the management and research of end-stage ankle arthritis.

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Level of Evidence: Level V, expert opinion. A: Good evidence (level I studies with consistent finding) for or against recommending intervention. B: Fair evidence (level II or III studies with consistent findings) for or against recommending intervention. C: Poor-quality evidence (level IV or V) for or against recommending intervention. I: There is insufficient or conflicting evidence not allowing a recommendation for or against intervention. Source: Wright JG, Einhorn TA, Heckman JD. Grades of recommendation.