A prospective, pivotal, multicenter field study to evaluate the dose regimen, effectiveness, and safety of levothyroxine sodium tablets, USP for the treatment of hypothyroidism and hypothyroidism-associated clinical signs in dogs was conducted. Ninety-two dogs diagnosed with primary hypothyroidism met the entrance criteria and were enrolled into the study. Levothyroxine sodium was administered to each dog on a daily basis either as the whole dose q 24 hr or as half the dose q 12 hr. Dosing started at 0.1 mg/10 lb (0.022 mg/kg) and continued for approximately 6 mo to Day 182. During this time, the thyroid status of each dog was evaluated at monthly intervals. For the determination of effectiveness, dogs classified as euthyroid at Day 182, based on their thyroid hormone values, were considered treatment successes. Results of the statistical analysis showed that there was no difference between the two dosing regimens (P = .11) and that when the data from both groups were pooled, the overall success rate was 75.64% (95% confidence interval = 66.34%). By Day 182, improvement and/or resolution of hypothyroidism-associated clinical signs was observed in all categories. No abnormal trends in the reported adverse events were observed.
Internal parasite control in commercial beef cow-calf operations in western Canada has, until recently, not been considered an important part of herd management. Recent epidemiological studies conducted in the region indicate however, that the cow is an important source of pasture contamination and hence infection for the calf (1). Studies conducted in North Dakota have demonstrated improved productivity and economic returns associated with treatment of the cow herd with ivermectin (2,3). Similar studies have not been published for western Canada.The objective of this study was to evaluate the productivity impact of a fall treatment with ivermectin of commercial beef cows. The effect of treatment was evaluated by monitoring the body condition and reproductive performance of cows and by measuring calf weight gains.
The IVOMEC SR Bolus is designed to release 12 mg of ivermectin per day for 135 days, providing therapeutic and prophylactic efficacy against existing and acquired infections of gastrointestinal roundworms, lungworms and external parasites.
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