a simple and possibly a successful method to treat and control this serious epidemic disease. Before applying this method to clinical trial here in China, we have endeavored to study its effectiveness in experimental infections, So far, the results obtained seem to indicate that with the dose employed, a significant protection has been obtained by means of this immune horse serum. The exact dosage and the possible therapeutic use of the serum after the appearance of the fever are subjects now under study.Calmettel has reported that the injection of cobra venom into a mouse carcinoma brought about a very rapid disappearance of the tumor, and he suggested that cobra venom might be of value in the treatment of other tumors. Monaelesser and Taguet2 injected cobra venom into the carcinomas of man, and they reported encouraging results.Our experiments were performed for the purpose of determining the effect of cobra venom when injected into the Fujinami rat sarcoma. The minimum lethal dose of cobra venom for white rats, weighing from 150 to 250 gm. each, was found to be one cc. of a 1:10,000 dilution. The solutions of cobra venom used were prepared according to the following technic described by Calmette. A 10% solution of desiccated cobra venom in normal saline was prepared and heated at 72°C. for 30 minutes. The solution, including the precipitate which was formed, was then centrifuged, and the clear portion was placed in ampoules and kept as a stock solution.Five rats were inoculated with bits of the Fujinami rat sarcoma which reached an average size of 0.5 x 0.5 x 1 cm. in Series 1.ICalmette, A., C. R. de E'acad. de Sc., 1933, 197, 205.
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