The profile of cognitive performance shows selective and progressive dysfunction of attention and executive function in patients with mild to moderate HD, consistent with frontostriatal pathology at this stage of disease.

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Elastic fibers are large, complex and surprisingly poorly understood extracellular matrix (ECM) macromolecules. The elastin fiber, generated from a single human gene - elastin (ELN), is a self assembling integral protein that endows critical mechanic proprieties to elastic tissues and organs such as the skin, lungs, and arteries. The biology of elastic fibers is complex because they have multiple components, a tightly regulated developmental deposition, a multi-step hierarchical assembly and unique biomechanical functions. Elastin is present in vocal folds, where it plays a pivotal role in the quality of phonation. This review article provides an overview of the genesis of elastin and its wide- ranging structure and function. Specific distribution within the vocal fold lamina propria across the lifespan in normal and pathological states and its contribution to vocal fold biomechanics will be examined. Elastin and elastin-derived molecules are increasingly investigated for their application in tissue engineering. The properties of various elastin– based materials will be discussed and their current and future applications evaluated. A new level of understanding of the biomechanical properties of vocal fold elastin composites and their molecular basis should lead to new strategies for elastic fiber repair and regeneration in aging and disease.

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Of 49 schizophrenicpatientsfollowed up 12 monthsafter their first admissionto hospital, onlyabout 45% had experiencedno relapseand had no schizophrenicsymptoms;a poorer outcome was moreoften found in Feighnerpositivethan Feighnernegativeschizophrenic patients. The patients' overall level of unemployment had more than doubled to 51 %. In patients whose acute episodesrespondedto treatment, pimozidetaken once weekly as maintenance therapy was as effective as intramuscularflupenthixol decanoate, but tardive dyskinesiaappeared in two patients receivingweekly pimozide;the repeat psy chometric assessmentat 12 months found modest improvements, i.e. no evidence of intellectual decline, in Matrices, Block Design, and Digit Copying tests. Forty per cent of relativesstillshowed significantpsychological distress,which correlatedwith patients' schizophrenicsymptoms, and the relatives' socialfunctioningremainedpoorerthan that of a normal community sample.

The APS Journal Legacy Content is the corpus of 100 years of historical scientific research from the American Physiological Society research journals. This package goes back to the first issue of each of the APS journals including the American Journal of Physiology, first published in 1898. The full text scanned images of the printed pages are easily searchable. Downloads quickly in PDF format.

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