Studies on the Circulation

Hamilton, W. F.; Moore, John W.; Kinsman, J. M.; Spurling, R. Glen

doi:10.1152/ajplegacy.1932.99.3.534

Cited by 646 publications

(34 citation statements)

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“…Kety and Schmidt, 10 Scheinberg and Stead, 17 Bernsmeier and Siemons, 18 and Lassen, 19 with their inert gas diffusion methods, have obtained mean values of about 50 to 65 ml./lOO Gm. of brain.…”

Section: Velocity Of Circulation In the Brainmentioning

confidence: 98%

“…The mathematical derivation of the equations can be found in an article by B. J. Andersson. 9 The equations are generalizations of a formula given earlier by Hamilton et al 10 The second method utilized the concentration curves obtained from samples taken from one carotid artery and the two bulbs after an intravenous injection was made. The formula is correct provided all the inflows show the same concentration curve and all the outflows show the same concentration curve.…”

mentioning

confidence: 99%

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Studies of the Cerebral Circulation with Labeled Erythrocytes in Healthy Man

Nylin¹,

Hedlung²,

Regnström³

1961

Circulation Research

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A thorough investigation of 10 healthy males, 26 to 46 years old, has been performed. One and a half ml. of their own erythrocytes, labeled with P 32 , was injected intravenously and dilution curves obtained simultaneously from one carotid artery and the two jugular bulbs. Thereafter, the same amount of labeled blood was injected into both carotid arteries, following one another, and dilution curves from the two jugular bulbs were simultaneously obtained. A total of seven dilution curves was collected in each case. The percutaneous punctures of the carotids were high enough in the neck so that it is highly probable that the injections were made into the internal carotid arteries. Calculations of the cerebral blood flow and the cerebral blood volume in absolute values were performed. The mean value of the cerebral blood flow amounted to 876 ml/min., i.e., 11.4 per cent of the cardiac output. The pool of the brain was calculated to about 100 ml. When a carotid artery was injected, the appearance and peak concentration times estimated from the dilution curves obtained from the ipsilateral bulbs were the same whether the injection was performed in the right or left side. The corresponding times for the dilution curves obtained from the contralateral bulb agreed, whichever the side on which the injection was performned. They were, however, one second longer than the ipsilateral ones. The determination of circulation time is of diagnostic value, according to an earlier publication. A simplified bloodless method has also been tried.

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Section: Velocity Of Circulation In the Brainmentioning

confidence: 98%

mentioning

confidence: 99%

Studies of the Cerebral Circulation with Labeled Erythrocytes in Healthy Man

Nylin¹,

Hedlung²,

Regnström³

1961

Circulation Research

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“…As previously mentioned, rather than using all the data points obtained, we have restricted our data-fitting to the initial time points of the first pass and analyzed the SI time curve using a mathematical equation based on indicator dilution theory (29) for calculating inverse mean transit time which is equal to the average time it takes any given particle of contrast agent to pass through the tissue. Mean transit time has been utilized previously with other, non-MR methods; for example, Rutishauser et al (30) calculated coronary blood flow by densitometrically determining mean transit time of the contrast medium through the arterial segment of interest.…”

Section: Calculation Of the Mbf Indexmentioning

confidence: 99%

Contrast‐enhanced first pass myocardial perfusion imaging: Correlation between myocardial blood flow in dogs at rest and during hyperemia

Wilke

Simm

Zhang

et al. 1993

Magnetic Resonance in Med

332

194

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The sensitivity of contrast-enhanced MR first pass perfusion imaging in detection and quantification of hypoperfused myocardium was evaluated using an instrumented, closed-chest dog model where graded regional hypoperfusion was induced by applying predetermined levels of stenosis to the left anterior descending artery (LAD). All measurements were performed at rest and under stress induced by dipyridamole (DIP). Myocardial perfusion was assessed both with MR and radiolabeled microspheres injected immediately before the administration of the MR contrast agent. Ultrafast MR imaging was performed using a Turbo FLASH sequence with a 180 degrees inversion prepulse. A Gd-DTPA bolus was injected into the left atrium and T1-weighted images were acquired with every heart beat. Signal intensity measured from the images in regions of the LAD and left circumflex (LCx) perfusion beds was plotted against time to generate signal intensity versus time curves (SI time curve). Various flow indices were derived according to the indicator dilution theory, and compared with and without volume correction due to vasodilation to the myocardial blood flow (MBF) calculated from radiolabeled microspheres. Correlation of the MR and MBF data demonstrated that different transmural and regional myocardial perfusion levels can be easily visualized in the perfusion images and accurately monitored by the SI time curves. Detection of the impairment of myocardial perfusion improved significantly after administration of DIP. The inverse mean transit time calculated from the SI time curve was found to yield a linear correlation to absolute MBF derived from the microsphere data. These results suggest that with intracardiac injections of exogenous contrast agent, myocardial perfusion can be assessed parametrically with first pass contrast enhanced ultrafast MRI.

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“…These findings accorded well with the sparse data then available (Hickam and Cargill. 1948;Riley et al, 1948;Dexter et al, 1951), and subsequent studies by other workers, I am pleased to say, have also shown remarkable agreement (Freedman et al, 1955 (Hamilton et al, 1932). Yet (Fig.…”

Section: Cardiac Output At Rest and On Exercisementioning

confidence: 59%

Exercise and Heart Disease

2009

Nutrition Reviews

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Studies on the Circulation

Cited by 646 publications

References 0 publications

Studies of the Cerebral Circulation with Labeled Erythrocytes in Healthy Man

Studies of the Cerebral Circulation with Labeled Erythrocytes in Healthy Man

Contrast‐enhanced first pass myocardial perfusion imaging: Correlation between myocardial blood flow in dogs at rest and during hyperemia

Exercise and Heart Disease

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