"Lethal midline granuloma" is an unusual but devastating spectrum of lymphoproliferative disorders that is now thought to include four entities: idiopathic midline destructive disease, Wegener's granulomatosis, polymorphic reticulosis, and nasal lymphoma. These disorders must be considered in the differential diagnosis of any patient with chronic, nonspecific complaints localized to the upper airway. An aggressive diagnostic and therapeutic approach may significantly decrease morbidity and death resulting from these lesions.
Head and Neck Surgery the patient's death. I realize that individual circumstances predicate the managements of difficult patients, but careful reviews of tissue biopsies should have been done before the patient's extensive sinus surgery. This is especially true for any patient with similar circumstances who does poorly and tissue pathology is seemingly nondiagnostic.
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