There are a number of different approaches to the assessment of doseproportionality, but most of these are directed toward hypothesis testing. The analysis of dose proportionality studies, however, requires estimation rather than significance testing in order that the pharmacokinetic and clinical significance of any nonproportionality can be assessed.The methods of statistical analysis of thesestudies have been reviewed. A n empirical model relating the log of thepharmacokineticparameter linearly to the log of the dose (the 'bower model") provides a readily interpreted measure of the degree of nonproportionality. The potential utility of this model has been demonstrated using a number of observed datasets from different drugs. If there is doubt over the goodness of f i t of the power model then analysis of variance (after log transformation), together with pairwise comparisons between doses, provides a suitable alternative approach.
Depressive symptoms impact subsequent physical symptoms of poor glucose control by influencing patients' ability to adhere to their self-care regimen. More aggressive management of depression among patients with diabetes may improve their physical health as well as their mental health.
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