Summary
A 45‐day‐old foal was presented for abdominal pain. Examination revealed the presence of haemoabdomen. An exploratory celiotomy was performed that revealed a large tear on the visceral surface of the spleen. A splenectomy was performed without rib resection. An abdominal wall hernia and leucocytosis had developed by 6 weeks post surgery. A second celiotomy to repair the hernia and explore the cause of the leucocytosis was performed 10 weeks after the first surgery. A portion of the caecum and colon had become adhered to the body wall at the site of the hernia; these areas were resected and the hernia repaired with a polypropylene mesh. The filly made a good recovery and is currently in training. Splenic rupture should be considered in any horse showing signs of abdominal pain with ultrasonographic findings consistent with haemoabdomen.
Bennett, D.A., J.J. DeFeo, E.E. Elko, and L. Harbans: Naloxone reversal of clonidine, but not hydralazine, hypotension. Drug Dev. Res. 2175Res. -179, 1982 Normotensive rats of the Sprague-Dawley strain were administered either the centrally acting hypotensive drug clonidine (0.16 mglkg IP) or the peripherally acting hypotensive drug hydralazine (1.25 rnglkg IP) to induce reliable hypotension (blood pressure reductions of 60-90 mm Hg), as measured by a tail cuff procedure. The opiate antagonist, naloxone (10-20 rnglkg IP), reversed clonidine but not hydralazine hypotension. Naloxone also failed to reverse hydralazine's hypotensive action in rats made hypertensive by renal ligation. Naloxone's reversal of clonidine (0.01 mglkg IV) hypotension was confirmed in experiments in which blood pressure was measured through direct cannulation of the carotid artery. It is suggested that naloxone's antagonism of clonidine hypotension is located at a central nervous system site, and that clonidine hypotension may be mediated through an interaction with the brain opiate systems.
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