, was a pioneer physician and neurologist who lived and practiced in Philadelphia. His interests ranged widely; in addition to his many medical papers and books he became equally well known as a poet and novelist publishing over 180 novels and books of poetry.Several of the medical syndromes, signs, and treatments he devised still are in use and carry his name.The S. Weir Mitchell Award, consisting of a bronze medallion, a honorarium, and the opportunity of presenting the research at the Academy meeting, is given annually to encourage research by young physicians and scientists in the general field of neurology.Dr. Seipel was honored for his Georgetown Clinical Research Institute studies in rheoencephalography, a simple, rapid, innocuous method of studying the brain circulation which had previously received little favorable interest in the United States. I n his paper, "The Biophysical Basis and Clinical Applications of Rheoencephalography," Dr. Seipel has demonstrated the high level of accuracy inherent in the method in diagnosing various forms of brain disease, developed a reliable procedure for its use, demonstrated its value in screening normal subjects for early, ,asymptomatic disease and demonstrated various hitherto unknown syndromes.This research was undertaken to develop rheoencephalography into a simple oflice procedure, comparable to electrocardiography, which could be used for certification and screening purposes to detect brain problems likely to cause sudden incapacity, such as stroke, prior to their occurrance and in sufficient time to begin adequate treatment.Dr. Seipel's receipt of the award in Philadelphia was particularly appropriate since he received part of his medical training at Pennsylvania Hospital; Dr. Mitchell was a member of that hospital's Board of Managers and probably also practiced there.iv
Two groups of six young normal male subjects were studied by an improved form of rheoencephalography (intracranial rheoncephalography), by photoplethysmography, and by impedance plethysmography to investigate the possible effects of single doses of betahistine hydrochloride (SERC) and placebo on the normal human cranial, cerebral, scalp, and calf circulations. Two subjects participated in both groups. The results of the two studies were similar and were combined for this presentation. One subject reported slight transient faintness and visual blurring after 20 mg of the drug. No other adverse or side effects were encountered. The results show that the drug causes definite, strong, reproducible, and dose-related responses in the studied circulations, typically those of decreases in their waveform amplitudes and pulse propagation times. Betahistine hydrochloride thus acts as a potent cerebral and peripheral microcirculatory vasodilator in normal humans when given orally. Split-dose studies indicate that responses followed each dose and that the second response was superimposed on the first. The value of using betahistine hydrochloride in overlapping doses is suggested. Atypical cranial, cerebral, scalp, and calf amplitude increases were found in some high-dosage (16-mg) trials. These increases may indicate that betahistine hydrochloride can also act as an arterial vasodilator in sufficiently high dosage, but they equally may indicate that sufficiently profound microcirculatory vasodilatation can elicit secondary arterial circulatory increases.
Zusammenfassung:Gegenstand und Ziel: Bestimmung der Prävalenz und Risikofaktoranalyse des Diabetes mellitus bei Hund und Katze am Patientenkollektiv der Tierärztlichen Hochschule Hannover. Material und Methoden: Retrospektiv wurden alle diabetischen Patienten der Klinik für Kleintiere der Tierärztlichen Hochschule Hannover in den Jahren 1996 bis 2006 nach Gewicht, Alter, Rasse und Geschlecht analysiert. Ergebnisse: In diesem 11-jährigen Untersuchungszeitraum litten 10 von 1000 Katzen und 4 von 1000 vorgestellten Hunden an Diabetes mellitus. Der feline Diabetes mellitus weist im Vergleich zum kaninen Diabetes mellitus eine steigende Tendenz auf. Im Geschlechtervergleich der Katzen repräsentieren kastrierte Kater mit 1,52% die größte Gruppe. Mit 0,79% sind kastrierte Hündinnen am häufigsten betroffen. Das Verhältnis von diabetischen Hündinnen zu Rüden liegt bei 2 : 1. Im Rassenvergleich ergibt sich bei Cairn Terrier und West Highland White Terrier eine erhöhte Inzidenz des Diabetes mellitus, während Schäferhunde und Dackel eine signifikant nierigere Prävalenz aufweisen. Schlussfolgerung: Die Prävalenz des Diabetes mellitus nimmt bei der Katze im Gegensatz zum Hund im norddeutschen Patientenkollektiv zu. An diesem Patientengut wurden folgende Risikofaktoren ermittelt: zunehmendes Alter, männliches Geschlecht und Gewicht für Katzen; mittleres Alter, weibliches Geschlecht und Kastration für Hunde. Klinische Relevanz: Die Entstehung des kaninen und felinen Diabetes mellitus ist multifaktoriell und daher nach wie vor eine große Herausforderung für Kliniker und Forscher. Aus diesem Grund kommt der Identifizierung von Risikofaktoren für das bessere Verständnis sowie die Erarbeitung neuer Präventionsmaßnahmen und Behandlungskonzepte herausragende Bedeutung zu.
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