1. Voltage-gated Ca2+ currents (ICa) and Ca2+-activated Cl-currents (Icl(ca)) were recorded from cultured rat dorsal root ganglion (DRG) neurones using the whole-cell configuration of the patch clamp technique. Intracellular photorelease of Ca2+ by flash photolysis of DM-nitrophen elicited transient inward currents only in those cells which possessed Ca2+_ activated Cl-tail currents following ICa. The reversal potential of the flash responses was hyperpolarized when extracellular Cl-was replaced by SCN-. The flash responses and the Ca2+-activated Cl-tail currents were inhibited by the Cl-channel blockers niflumic acid (10-100 /SM) and 5-nitro-2-(3-phenylpropylamino)benzoic acid (NPPB) (10 /1M).
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