IMPORTANCEOlder patients and those with comorbidities who are infected with SARS-CoV-2 may be at increased risk of hospitalization and death. Sotrovimab is a neutralizing antibody for the treatment of high-risk patients to prevent COVID-19 progression.OBJECTIVE To evaluate the efficacy and adverse events of sotrovimab in preventing progression of mild to moderate COVID-19 to severe disease.DESIGN, SETTING, AND PARTICIPANTS Randomized clinical trial including 1057 nonhospitalized patients with symptomatic, mild to moderate COVID-19 and at least 1 risk factor for progression conducted at 57 sites in Brazil, Canada,

No abstract

Topographical changes on vicinal Si(111)have been followed as a function of submonolayer Au coverage. Nucleation at step edges leads to subsequent growth of a single-domain overlayer of the Auinduced 5X2 structure. Phase boundaries between step, 7X7 and 5X2 regions have been studied, as well as the detailed structure of the step and 5 X2 regions. Gradual changes in facet angle on the surface occurred, driven by 5X2 terrace growth. An inhomogeneous coverage of Au was observed, with a pattern extending over distances on the order of micrometers, indicating large-scale surface diffusion of both Au and Si atoms.

Reflectance anisotropy spectroscopy is applied to submonolayer growth of In on the vicinal silicon (111) surface. Deposition in the region of 1 monolayer onto a clean stepped Si(111) surface at elevated temperature produces a single-domain In-induced (4×1) superstructure consisting of quasi-one-dimensional chains aligned parallel to the vicinal surface step edges. A significant optical anisotropy (1.65%), uncharacteristic of semiconductor systems, develops in the region of 1.9 eV which saturates upon completion of the (4×1) superstructure. We relate this feature to an optical transition involving a flat, highly populated filled surface state observed previously. We argue that the intensity and direction of this peak are indicative of electronic confinement within this system perpendicular to the In-induced chain length.

No abstract