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The canalicular type of monomorphic adenoma is a rare salivary gland tumor that has had infrequent notice in the literature. Twenty‐nine cases from the files of the AFIP are analyzed. The tumor presents a unique histologic pattern composed of cords and ducts of uniform epithelium. This entity occurs in an older age group (median 60 years) than the pleomorphic adenoma and has a pronounced proclivity for the upper lip. It is seen with approximately equal frequency in male and female patients, and in this study was found only in Caucasians. The lesion has a benign course and exhibits no tendency for recurrence. This type of monomorphic adenoma should be considered a histopathologic entity with a number of clinical features in common with the more frequently occurring pleomorphic adenoma.

Advances in molecular biology are enabling rapid and efficient analyses for effective intervention in domains such as biology research, infectious disease management, food safety, and biodefense. The emergence of microfluidics and nanotechnologies has enabled both new capabilities and instrument sizes practical for point-of-care. It has also introduced new functionality, enhanced sensitivity, and reduced the time and cost involved in conventional molecular diagnostic techniques. This chapter reviews the application of microfluidics for molecular diagnostics methods such as nucleic acid amplification, next-generation sequencing, high resolution melting analysis, cytogenetics, protein detection and analysis, and cell sorting. We also review microfluidic sample preparation platforms applied to molecular diagnostics and targeted to sample-in, answer-out capabilities

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