We analyzed by multilocus sequence typing 77 lymphogranuloma venereum Chlamydia trachomatis strains from men who have sex with men in Europe and the United States. Specimens from an outbreak in 2003 in Europe were monoclonal. In contrast, several strains were in the United States in the 1980s, including a variant from Europe.
2 women, 62 and 69 years old, both suffering from rheumatoid arthritis, were treated for 1 and 1½ years, respectively, with penicillamine. Both developed a bullous eruption which according to clinical and histological picture, immunofluorescence studies and to light provocation, as well as in 1 case to antinuclear antibody findings corresponded to pemphigus erythematosus. In spite of treatment with prednisone and azathioprine, they still keep developing bullae.
A 44-year-old woman with rheumatoid arthritis and vasculitis of the skin developed a lupus erythematosus-like reaction after 5 weeks of D-penicillamine therapy. The diagnosis was established on the clinical and histological picture, immunofluorescence studies and serological investigations. The reaction faded upon cessation of the drug.
Summary
A pilot study on the efficiency of treatment with 8‐methoxypsoralen and longwave ultraviolet light (PUVA) on three patients with allergic contact dermatitis to nickel sulphate, potassium dichromate and to thiuram mix has been performed. Both the contact allergic reactions and the irritative skin reactions induced by dimethyl sulfoxide (DMSO) and tetrahydrofurfuryl nicotinate (Trafuril) were evaluated before and after PUVA. The total UV‐A doses were respectively 69–45 and 76J/cm2. These doses induced complete clearance of the eczematous lesions in two cases; the third case showed considerable improvement. In contrast to the pronounced skin reactions seen prior to PUVA, the allergic and irritative reactions evaluated after PUVA were decreased or negative.
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