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Restoration of the mechanical leg axis and component positioning are crucial factors affecting long-term results in total knee arthroplasty (TKA). In a prospective study, 1,000 patients were operated on either using a CT-free navigation system or the conventional jig-based technique. Leg alignment and component orientation were determined on postoperative X-rays. The mechanical leg axis was significantly better in the computer-assisted group (95%, within +/-3 degrees varus/valgus) compared to the conventional group (74%, within +/-3 degrees varus/valgus) (P < 0.001). On average, the operating time was increased by 8 min in the computer-assisted group. No significant differences were seen between senior and younger surgeons regarding postoperative leg alignment and operating time. Computer-assisted TKA leads to a more accurate restoration of leg alignment and component orientation compared to the conventional jig-based technique. Potential benefits in long-term outcome and functional improvement require further investigation.

The absence of SP and SNF reduces pain sensitivity and mechanical stability of the bone in general. The micro-architecture of the bone is profoundly impaired in the absence of intact SNF with a less drastic effect in SP-deficient mice. Both sympathetic and sensory neurotransmitters are indispensable for proper callus differentiation. Importantly, the absence of SP reduces bone formation rate whereas the absence of SNF induces bone resorption rate. Notably, fracture chondrocytes produce SP and its receptor NK1 and are positive for α-adrenoceptors indicating an endogenous callus signaling loop. We propose that sensory and sympathetic neurotransmitters have crucial trophic effects which are essential for proper bone formation in addition to their classical neurological actions.

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Background and purpose Many studies have suggested that navigation-based implantation can improve cup positioning in total hip arthroplasty (THA). We conducted a systematic review and meta-analysis to compile the best available evidence, and to overcome potential shortcomings because of small sample sizes in individual studies.Methods The search strategy covered the major medical databases from January 1976 through August 2007, as well as various publishers' databases. The internal validity of individual studies was evaluated independently by 3 reviewers. We used random-effects modeling to obtain mean differences in cup angulation and relative risk (RR) of cup positioning outside Lewinnek's safe zone.Results Of 363 citations originally identified, 5 trials of moderate methodology enrolling a total of 400 patients were included in the analysis. Mean cup inclination and anteversion were not statistically significantly different between the conventional groups and the navigated groups. Navigation reduced the variability in cup positioning and the risk of placing the acetabular component beyond the safe zone (RR = 0.21, CI: 0.13–0.32).Interpretation Based on the current literature, navigation is a reliable tool to optimize cup placement, and to minimize outliers. However, long-term outcomes and cost utility analyses are needed before conclusive statements can be drawn about the value of routine navigation in THA.

The prevention of hip fractures is a desirable goal to reduce morbidity, mortality, and socio-economic burden. We evaluated the influence on femoral strength of different clinically applicable cementing techniques as ''femoroplasty.'' Twenty-eight human cadaveric femora were augmented by means of four clinically applicable percutaneous cementing techniques and then tested biomechanically against their native contralateral control to determine fracture strength in an established biomechanical model mimicking a fall on the greater trochanter. The energy applied until fracture could be significantly increased by two of the methods by 160% (53.1 Nm vs. 20.4 Nm, p < 0.001) and 164% (47.1 Nm vs. 17.8 Nm, p ¼ 0.008), respectively. The peak load to failure was significantly increased by three of the methods by 23% (3818.3 N vs. 3095.7 N, p ¼ 0.003), 35% (3698.4 N vs. 2737.5 N, p ¼ 0.007), and 12% (3056.8 N vs. 2742.8 N, p ¼ 0.005), respectively. The femora augmented with cemented double drill holes had a lower fracture strength than the single drilled ones. Experimental femoroplasty is a technically feasible procedure for the prophylactic reinforcement of the osteoporotic proximal femur and, hence, could be an auxiliary treatment option to protect the proximal femur against osteoporotic fractures. ß

Minimal invasive surgery (MIS) in total knee replacement (TKR) has been favoured by several authors and the industry and is asked for by the patients. Computer assisted surgery (CAS) is proposed to support the surgeon in terms of postoperative leg alignment and implant orientation. To prove the hypothesis that MIS in TKR fastens early rehabilitation compared to the standard approach and that CAS-MIS in TKR improves accuracy in implant position compared to the freehand MIS and freehand standard technique, we performed a prospective, randomised short-term trial which was approved by the local ethic committee. In total, 90 patients underwent TKR. The conventional group (n = 30) underwent conventional TKR, the MIS group (n = 30) underwent MIS-TKR without navigation, the CAS-MIS group (n = 30) underwent TKR using navigation and the MIS approach. Groups were comparable regarding patients' specific parameters. The length of incision in extension was significantly lower in the MIS (13.2 cm) and CAS-MIS technique (12.9 cm) compared to the conventional technique (17.3 cm) (P < 0.01). Knee Society and WOMAC Score were similar in all three groups after 1, 6 and 12 weeks, no significant differences were seen between groups at any point of time. Postoperative deviation of the mechanical leg axis was significantly better in the CAS-MIS group compared to the conventional group and the MIS one (P < 0.05). The clinical relevance of our results is that the benefit of the minimal invasive approach in TKR is still not proven and navigation improves postoperative accuracy of leg alignment and component orientation. Our study shows that for the group of patients included there is no statistically significant difference in early rehabilitation between MIS and the conventional approach based on the Knee Society and WOMAC Score. Using the CAS technique restoration of leg axis was more accurate.

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