Bisphosphonates or prostacyclin in the treatment of bone-marrow oedema syndrome of the knee and foot

Baier, Christel; Schaumburger, Jens; Götz, Jürgen; Heers, G.; Schmidt, Thorsten; Grifka, Joachim; Beckmann, Johannes

doi:10.1007/s00296-012-2584-0

Cited by 60 publications

(80 citation statements)

References 23 publications

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“…Measures to shorten this natural history should initially be partial weight-bearing, immobilization, analgesics and anti-inflammatory medication. Additional treatment approaches include extracorporeal shock wave therapy, bisphosphonates, and iloprost [1,3,29,[110][111][112]. Regarding pharmaceutical therapy, we recommend zoledronate 5 mg IV as primary treatment and iloprost administered for a total dose of 180 µg IV over 5 days (day 1: 20 µg over 6-8 h; day 2-5: dose increase to 40 µg per day over 6-8 h).…”

Section: Bone Marrow Edema Syndrome (Bmes)mentioning

confidence: 99%

How We Manage Bone Marrow Edema—An Interdisciplinary Approach

Baumbach

Pfahler

Pozza

et al. 2020

JCM

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Bone marrow edema (BME) is a descriptive term for a common finding in magnetic resonance imaging (MRI). Although pain is the major symptom, BME differs in terms of its causal mechanisms, underlying disease, as well as treatment and prognosis. This complexity together with the lack of evidence-based guidelines, frequently makes the identification of underlying conditions and its management a major challenge. Unnecessary multiple consultations and delays in diagnosis as well as therapy indicate a need for interdisciplinary clinical recommendations. Therefore, an interdisciplinary task force was set up within our large osteology center consisting of specialists from internal medicine, endocrinology/diabetology, hematology/oncology, orthopedics, pediatrics, physical medicine, radiology, rheumatology, and trauma surgery to develop a consenus paper. After review of literature, review of practical experiences (expert opinion), and determination of consensus findings, an overview and an algorithm were developed with concise summaries of relevant aspects of the respective underlying disease including diagnostic measures, clinical features, differential diagnosis and treatment of BME. Together, our single-center consensus review on the management of BME may help improve the quality of care for these patients.

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Section: Bone Marrow Edema Syndrome (Bmes)mentioning

confidence: 99%

How We Manage Bone Marrow Edema—An Interdisciplinary Approach

Baumbach

Pfahler

Pozza

et al. 2020

JCM

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“…Также было зафиксировано отчетливое снижение ОКМ в 47% и полная регрессия в 40%. При сравнении обеих групп улучшение показателей было больше в группе простациклина, чем в группе бисфосфоната, однако разница не была существенной [31].…”

Section: влияние консервативной терапии на отек костного мозгаunclassified

Clinical significance of bone marrow edema in the late stages of osteoarthritis

2020

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The use of magnetic resonance imaging (MRI) for osteoarthritis made it possible to simultaneously detail the state of cartilage, subchondral bone, menisci, ligaments, and synovial membrane. In some studies, a correlation was found between bone marrow edema (BME) and the intensity of the pain syndrome, the progression of OA and the risk of total knee replacement. In other studies, these data were not confirmed. It has been suggested that BME in OA, leading to debilitating pain, is not associated with trauma and is determined by an increase in extracellular fluid. Analysis of MRI images of 80 patients with 1-3 stages of knee osteoarthritis revealed a statistically significant relationship between the presence of bone marrow edema and the thickness of the cartilage of the femur and tibia, rupture and degradation of the medial menisci, the presence of Baker cysts and thickening of the synovial membrane. No reliable relationship was found with the presence and severity of synovitis. A review of data on the effect of various methods of conservative therapy on bone marrow edema in osteoarthritis is presented. The effect of anti-osteoporotic drugs, prostacyclin, Pentosan polysulfate sodium chondroitin sulfate is considered. Thus, OKM is of interest both in terms of the pathogenesis of OA and as an indicator of the effectiveness of the treatment of OA. Our data demonstrate a high incidence of OKM in the late stages of OA. The effect of pharmacological therapies on OKM requires further study.

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“…Kalçada GBO tanısı konulan 5 olguya hiperbarik oksijen tedavisi uygulanmış ve olguların semptomlarının ortalama 16 haftada azaldığı, 22 haftada MRG bulgularında düzelme olduğu bildirilmiştir (22). Çalışmalarda ve olgu sunumlarında medikal tedavi olarak bifosfanat, teriparatid veya prostasiklin tedavileri ile daha erken düzelme olduğu bildirilmiştir (14,17,23,24). Tedavide bifosfanatlardan alendronat, pamidronat, klodranat, ibandronat ve zoledronik asit kullanılmıştır (14,25).…”

Section: Olgu Sunumuunclassified

Regional Migratory Osteoporosis: A Case Report

Atici¹,

Akpinar²,

Özkan³

et al. 2018

Tod

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Regional migratory osteoporosis is characterized by migratory transient regional osteoporosis attacks. The etiology is not explained completely. Although it is a self-limiting benign disease, it causes serious arthralgia in involved joint and loss of labor force. It is important to make the differential diagnosis with many diseases which causes bone marrow edema. Therefore, herein we present a fifty-four-year old male patient diagnosed with regional migratory osteoporosis of the hip, knee, and ankle involvement.

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Bisphosphonates or prostacyclin in the treatment of bone-marrow oedema syndrome of the knee and foot

Cited by 60 publications

References 23 publications

How We Manage Bone Marrow Edema—An Interdisciplinary Approach

How We Manage Bone Marrow Edema—An Interdisciplinary Approach

Clinical significance of bone marrow edema in the late stages of osteoarthritis

Regional Migratory Osteoporosis: A Case Report

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