In this article, the antioxidant activity of some alkaloids lipid peroxidation (LPO) in rat liver mitochondria has been studied. It has been established that diterpenoid alkaloids: 1-О-benzoylnapelline, napelline and songorine have a protective effect on mitochondria, reducing the damaging effect of Fe2+/ascorbate and the release of malondialdehyde (MDA) into the secondary products of peroxidation. The effect of alkaloids napelline, 1-O-benzoylnapelline and songorine on the processes of MDA formation in rat liver mitochondria in vitro has been studied.Where in at 200 мM concentrations, 1-О-benzoylnapelline inhibited the formation of MDA by 95 %, and the alkaloids napelline and songorine at this concentration inhibited the formation of MDA by 54 and 44 %. From the data obtained, it can be shown that 1-О-benzoylnapelline strongly inhibits the formation of MDA compared to songorine and napelline.
The problem of anthropogenic impact of the Tudakul reservoir has not been spared. In the first years of the reservoir’s existence, its ichthyofauna was formed by the fish of the Zarafshan River, which were represented by both rheophiles and limnophiles, and initially it consisted of 11 aboriginal species and introduced fish. This paper gives a brief physical-geographical, hydrological, hydrochemical, hydrobiological characteristics of the Tudakul reservoir. An assessment of the ecological state of the reservoir, ichthyofauna and fish catch in it over the past decade is given. Recommendations for the rational use of the Tudakul reservoir are given.
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