Background The French PRODIGE 7 trial, published on January 2021, has raised doubts about the specific survival benefit provided by HIPEC with oxaliplatin 460 mg/m2 (30 minutes) for the treatment of peritoneal metastases from colorectal cancer. However, several methodological flaws have been identified in PRODIGE 7, specially the HIPEC protocol or the choice of overall survival as the main endpoint, so its results have not been assumed as definitive, emphasizing the need for further research on HIPEC. It seems that the HIPEC protocol with high-dose mytomicin-C (35 mg/m2) is the preferred regime to evaluate in future clinical studies. Methods GECOP-MMC is a prospective, open-label, randomized, multicenter phase IV clinical trial that aims to evaluate the effectiveness of HIPEC with high-dose mytomicin-C in preventing the development of peritoneal recurrence in patients with limited peritoneal metastasis from colon cancer (not rectal), after complete surgical cytoreduction. This study will be performed in 31 Spanish HIPEC centres, starting in March 2022. Additional international recruiting centres are under consideration. Two hundred sixteen patients with PCI ≤ 20, in which complete cytoreduction (CCS 0) has been obtained, will be randomized intraoperatively to arm 1 (with HIPEC) or arm 2 (without HIPEC). We will stratified randomization by surgical PCI (1–10; 11–15; 16–20). Patients in both arms will be treated with personalized systemic chemotherapy. Primary endpoint is peritoneal recurrence-free survival at 3 years. An ancillary study will evaluate the correlation between surgical and pathological PCI, comparing their respective prognostic values. Discussion HIPEC with high-dose mytomicin-C, in patients with limited (PCI ≤ 20) and completely resected (CCS 0) peritoneal metastases, is assumed to reduce the expected risk of peritoneal recurrence from 50 to 30% at 3 years. Trial registration EudraCT number: 2019–004679-37; Clinicaltrials.gov: NCT05250648 (registration date 02/22/2022, ).

The search for remedies to treat dental disease is as old as mankind; such is the importance of the stomatognathic system (mouth, jaws, teeth and related structures) in the evolution of man and society. This paper concentrates on the Kitab al-tasrif, a medical treatise completed in 1000 CE by the famous Arab physician, surgeon and pharmacologist Abulcasis (Abu al-Qasim al Zahrawi; 936-1013), from Córdoba (Andalusia, southern Spain). Volume (Maqal) XXI of this 30-volume-long work, is dedicated to mineral panaceas for diseases of the mouth and teeth. The remedies detailed by Abulcasis are compared with those in Dioscorides' much earlier Materia Medica (first century CE), the later Hortus sanitatis (1496) by Johannes de Cuba and recent pharmacopoeias to trace and evaluate the evolutionary path of mineral-containing drugs and dental compounds, and to account for the survival of many of them in therapeutic compounds. Although effective, some of the old mineral remedies have a narrow therapeutic range and have no place in current pharmacology; however, many of them are still useful as astringents, haemostatics, antiseptics, teeth whiteners, remineralizers or caustics.

OBJETIVO: comprender y reconstruir las teorías subjetivas de profesionales de escuelas de lenguaje en Chile, sobre las causas y el tratamiento del trastorno específico del lenguaje. MÉTODO: se utilizó métodos cualitativos para recolectar datos en profundidad. Se realizó entrevistas individuales semi-estructuradas con una muestra de cuatro fonoaudiólogas (logopedas) y cuatro educadoras diferenciales de cuatro escuelas de lenguaje. Se grabó y transcribió las entrevistas, las que fueron analizadas con el programa informático Atlas.ti 5.0. Los resultados del análisis relacional se sintetizaron en tres modelos. RESULTADOS: para las fonoaudiólogas y educadoras diferenciales las causas principales del trastorno específico del lenguaje son factores sociales, originados en la familia de los niños afectados. Con respeto a la superación de este trastorno las entrevistadas destacaron con alta importancia el apoyo familiar para un tratamiento eficaz. CONCLUSIONES: entre las explicaciones subjetivas de las profesionales entrevistadas y las explicaciones científicas acerca las causas del trastorno específico del lenguaje, existen diferencias. Mientras las entrevistadas hablan de causas sociales, los enfoques científicos explican este trastorno por causas biológicas. Esta diferencia debería ser investigada en estudios posteriores. Las fonoaudiólogas y educadoras diferenciales ven la familia del niño como una de las causas principales del trastorno específico del lenguaje y al mismo tiempo consideran el apoyo familiar como un requisito crucial en el tratamiento. En la opinión de los profesionales de las escuelas de lenguaje el trastorno específico del lenguaje es un trastorno superable, si escuela y familia trabajan en conjunto.

RESUMENLa obra "Perì líthon" o "Tratado de Piedras" de Teofrasto, es considerado el texto más antiguo conservado sobre minerales y rocas, aunque haya llegado hasta nosotros incompleto. En este trabajo se analiza su contenido comparándolo con el de otros lapidarios antiguos y se concluye que once de las piedras que refiere y que vienen indicadas con nombres geográficos o crípticos son fósiles de plantas, vertebrados o químicos. Por eso, esta obra debe considerarse también como el tratado más antiguo que conocemos sobre paleontología, pues además de los fósiles que menciona, en ella se alude expresamente al proceso de fosilización.Palabras clave: Criptopaleontología, Teofrasto, historia de la geología. ABSTRACTThe work "Perì líthon" or Teofrasto's "Treatise of stones" has been considered the oldest text still available about minerals and rocks, even though it has remained incomplete. In this paper, the study of its contents shows that eleven of the stones called by geographic or cryptic names are either fossils from plants or vertebrates or chemical fossils. Therefore, the "Perì líthon" should also be considered as the oldest known treatise about palaeontology, because in addition to the fossils mentioned, it refers specifically to the fossilisation process.

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