Background: Asthma prevalence is 339 million globally. 'Severe asthma' (SA) comprises subjects with uncontrolled asthma despite proper management. Objectives: To compare asthma from diverse ethnicities and environments. Methods: A cross-sectional analysis of two adult cohorts, a Brazilian (ProAR) and a European (U-BIOPRED). U-BIOPRED comprised of 311 non-smoking with Severe Asthma (SAn), 110 smokers or ex-smokers with SA (SAs) and 88 mild to moderate asthmatics (MMA) while ProAR included 544 SA and 452 MMA. Although these projects were independent, there were similarities in objectives and methodology, with ProAR adopting operating procedures of U-BIOPRED. Results: Among SA subjects, age, weight, proportion of former smokers and FEV 1 pre-bronchodilator were similar. The proportion of SA with a positive skin prick tests (SPT) to aeroallergens, the scores of sino-nasal symptoms and quality of life were comparable. In addition, blood eosinophil counts (EOS) and the % of subjects with EOS > 300 cells/μl were not different. The Europeans with SA however, were more severe with a greater proportion of continuous oral corticosteroids (OCS), worse symptoms and more frequent exacerbations. FEV 1 /FVC pre-and post-bronchodilator were lower among the Europeans. The MMA cohorts were less comparable in control and treatment, but similar in the proportion of allergic rhinitis, gastroesophageal reflux disease and EOS >3%. Conclusions: ProAR and U-BIOPRED cohorts, with varying severity, ethnicity and environment have similarities, which provide the basis for global external validation of asthma phenotypes. This should stimulate collaboration between asthma consortia with the aim of understanding SA, which will lead to better management.

Objetivo: Estimar a incidência e descrever as comorbidades de todos os casos de tuberculose notificados ao Sistema Nacional de Agravos de Notificação (SINAN) do município de Campo Grande/MS. Métodos: Trata-se de uma pesquisa transversal de dados secundários que analisou todos os 2806 casos notificados ao Sistema Nacional de Agravos de Notificação no município de Campo Grande/MS, período de janeiro de 2014 a dezembro de 2019. Resultados: A taxa de incidência no município variou no período de 31,56 a 51,42 casos/100 mil habitantes. Observou-se predomínio no sexo masculino (80,3%). Quanto às comorbidades, 70,5% apresentaram pelo menos uma. O tabagismo foi o agravo mais prevalente (27%), seguido pelo uso de substâncias psicoativas, álcool e coinfecção pelo vírus HIV/Aids (13,8%). O diabetes foi a doença menos prevalente com 5,4%, o que difere das taxas nacionais. A modalidade de Tratamento Diretamente Observado foi realizada em 3,8% dos casos, taxa muito inferior a nacional. Conclusão: Evidenciou-se a possível ocorrência de atraso do diagnóstico. Um terço dos casos de tuberculose foram diagnosticados nos hospitais. O coeficiente de incidência no município foi superior ao do estado e do Brasil, principalmente nos anos d e108 e 2019, com uma taxa de incidência de 51,42 e 41,6, respectivamente.

Objetivos: identificar a causa de morte infantil hospitalar, correlacionando-a com as causas evitaveís de mortalidade e associando-a com a prevalência do município. Métodos: a pesquisa foi realizada utilizando como base de informações as certidões de óbitos e prontuários arquivados no Hospital Regional do Mato Grosso do Sul, dos quais foram selecionados os óbitos do período de 2012 a 2017 de crianças menores de 5 anos e foram analisados as variáveis sociodemográficas e causas das mortes. Resultados: ocorreram 364 mortes infantis no período, sendo que 75% dos óbitos registrados são classificados como causas evitáveis de óbitos infantis. Conclusão: são necessárias ações para a qualificação de recursos humanos e estruturas de saúde no âmbito hospitalar com enfoque nas causas evitáveis, sendo mandatório a atualização dos indicadores de mortalidade infantil, visto que representam a efetividade dos serviços de saúde e fazem parte da vigilância epidemiologia no âmbito da saúde coletiva.

Introduction: The Bioceanic Routeand its economic integration will have tremendous impact within the cities under management. The state of Mato Grosso do Sul and interior municipalities of the Paraguay-Brazil Border are standouts. The permanence of these workers in Brazilian territory will lead to a rapid increase in population in the border towns connected by the corridor and consequently, in the incidence of infectious diseases. Methods: This is a cross-sectional, quantitative and descriptive study of documentary approach that aimed to analyze the prevalence of tropical infectious diseases such asarboviroses and Diseases Related to Inadequate Environmental Sanitation (DRIES) notified and stored in the National System of Notifiable Diseases (SINAN). The sample consisted of new cases of these pathologies in the municipality of Porto Murtinho registered between January 2017 and December 2020. Results: Within the period analyzed, an increase of 10% in the total number of diseases occured. The number of dengue cases increased 36 times its previous rates; there was a maintenance from cases of Leptospirosis, Yellow Fever, Zika, Chikungunya, whereas the incidence of Syphilis, HIV and HPV decreased. Conclusions: Actions aimed at preventing the increase of Arboviruses and DRIESI before, during and after the construction of the Bioceanic Route are needed in view of the changes that will be imposed by it. Faced with the increase in the flow of people that is inevitable with the construction of this project, several outcomes are expected based on previous experiences already mentioned in this work.

This study aims to assess the epidemiological situation of five municipalities that are part of the bioceanic route in order to analyze the descriptors and general health aspect of the population through a retrospective, quantitative and cross-sectional descriptive study with a documentary approach, from secondary data reported to the National System of Notifiable Diseases in the municipalities of Guia Lopes da Laguna, Jardim, Nioaque, Porto Murtinho, Sidrolândia and Campo Grande, in the state of Mato Grosso do Sul, in the period from January 2015 to December 2020. The incidence rate ranged between 32.23 and 79.4 cases/100,000 inhabitants. There was a predominance of individuals aged between 30-39 years (26.05%) and males (67.5%). The most important injuries were alcoholism (19.15%) and smoking (18%). In the exams, 52.3% had positive bacilloscopy and 32.03% had a positive culture. The incidence of tuberculosis in the evaluated municipalities was higher than the Brazilian average and that of the state of Mato Grosso do Sul. These evaluated municipalities do not have a favorable epidemiological situation with regard to tuberculosis and the construction of the biocenic route may further aggravate the situation.

Background: Tuberculosis remains among the most prevalent infectious diseases worldwide, Risk factors include sociodemographic factors and comorbidities such as alcohol consumption, diabetes mellitus, the use of legal and illegal drugs and HIV. This research aimed to estimate the incidence of tuberculosis cases and describe the epidemiological profile of all tuberculosis cases reported to the National System of Notifiable Diseases in the city of Campo Grande/MS, correlating with national and international literature. Methods: This is a cross-sectional survey of secondary data that analyzed all cases reported in the city from January 2014 to December 2019. Results: There was a predominance of males (80.3%). The most affected age group corresponded to individuals of working age (20 to 59 years), with 84% of the total data. As for comorbidities, 70.5% had at least one. Smoking was the most prevalent health issue (27%), followed by the use of psychoactive substances, alcohol consumption and HIV/Aidsco-infection (13.8%). Diabetes was the lowest rated disease, with 5,4%. Conclusions: The data obtained points to the need to assess the directly observed treatment (DOT) in the capital, given the alarming rate of adherence od 3.8%. About one third of tuberculosis cases were diagnosed in hospitals, supporting the hypothesis of delayed diagnosis, which leverages the need for health actions on the subject.

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