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. 64, 76 (1986). The electrochemical oxidation of aromatic heterocyclic compounds thiophene, pyrrole, and indole and benzenoid and nonbenzenoid polycyclic hydrocarbons azulene, fluorene, and pyrene yield electrically conducting polymers with conductivities of 10-5-10 S/cm. The presence of substituents affects the electrical conductivity of these films and also their electroactive properties. Furthermore, substituents determine whether electropolymerization of these compounds can occur or whether soluble products are formed. The relative importance of these pathways is dependent on the stability of the intermediate radical cation. These effects are investigated by INDO molecular orbital calculations.

The PASADENA or PHIP effect originates from the breakdown of the parahydrogen symmetry when the two protons are found in magnetically inequivalent positions after hydrogenation. As a result, a signal enhancement of up to 104 in the proton NMR spectra can be observed. We introduce three polarization transfer techniques, namely PH-INEPT, PH-INEPT+, and INEPT(+π/4), that are highly effective to record in situ hetero NMR spectra of parahydrogen-labeled compounds. A complete product operator treatment as well as experimental results for 13C and 29Si have been given. With these sequences we obtained a signal enhancement of 500 which allows in situ NMR investigations of hetero nuclear systems at natural abundance.

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Ceftaroline fosamil achieved high clinical cure and microbiological response rates in patients hospitalized with CAP of PORT risk class III or IV. Ceftaroline fosamil was well tolerated, with a safety profile that is similar to that of ceftriaxone and other cephalosporins. Ceftaroline fosamil is a promising agent for the treatment of CAP.

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