Three-component Mannich reactions of aromatic aldehydes, anilines and acetophenone were efficiently catalyzed by a recyclable carboxyl-functionalized ionic liquid ([cmmim][BF 4 ]) in aqueous [bmim] [BF 4 ] under mild conditions. Twelve b-aminoketones were successfully synthesized in high yields and the catalyst can be recycled at least 6 times without significant loss of activity.
A microwave-assisted solid phase synthesis of aminochalcones via the Claisen–Schmidt condensation reaction between resin-bound p-aminoacetophenone and aromatic aldehydes was described.
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