the oxidative stress. [1] Multiple oxidation states in metals grant the redox nature by which the detrimental amount of reactive oxygen species (ROS) is quenched. [1,2] However, the dynamic adsorption of small molecules and proteins on the nanomaterials becomes problematic when the active sites for the intended biochemical reaction are obstructed or altered. [3][4][5] Abundant redox-active molecules such as glutathione
Restoring hair follicles by inducing the anagen phase is a promising approach to prevent hair loss. Hair follicle dermal papilla cells (HFDPCs) play a major role in hair growth via the telogen-to-anagen transition. The therapeutic effect of Morus alba activates β-catenin in HFDPCs, thereby inducing the anagen phase. The HFDPCs were treated with M. alba root extract (MARE) to promote hair growth. It contains chlorogenic acid and umbelliferone and is not cytotoxic to HFDPCs at a concentration of 20%. It was demonstrated that a small amount of MARE enhances growth factor secretion (related to the telogen-to-anagen transition). Activation of β-catenin was observed in MARE-treated HFDPCs, which is crucial for inducing the anagen phase. The effect of conditioned medium derived from MARE-treated HFDPCs on keratinocytes and endothelial cells was also investigated. The findings of this study demonstrate the potency of MARE in eliciting the telogen-to-anagen transition.
Bhang, and co-workers report the therapeutic effect of copper-deposited ceria nanoparticles (CuCe NPs) on ischemic vascular diseases. They exhibit enhanced antioxidant effects over pristine ceria nanoparticles as the released copper buffers the depletion of glutathione while providing the bioavailable copper as a cofactor for the antioxidant enzyme, superoxide dismutase 1.
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