Ceria Nanoparticles as Copper Chaperones that Activate SOD1 for Synergistic Antioxidant Therapy to Treat Ischemic Vascular Diseases (Adv. Mater. 16/2023)

Abstract

Bhang, and co-workers report the therapeutic effect of copper-deposited ceria nanoparticles (CuCe NPs) on ischemic vascular diseases. They exhibit enhanced antioxidant effects over pristine ceria nanoparticles as the released copper buffers the depletion of glutathione while providing the bioavailable copper as a cofactor for the antioxidant enzyme, superoxide dismutase 1.

Nanomedicine‐Based Therapeutics for Myocardial Ischemic/Reperfusion Injury

“…Another favorable method to achieve intelligent cargo delivery in myocardial ischemic therapy includes the smart-responsive strategies induced by external stimuli such as ultrasound, light, and hyperthermia. Addition- PDA ROS-scavenging IR Intravenous injection [111] Mito-Fenozymes SOD-and CAT-mimetic IR Intravenous injection [113] CuZn CDs SOD-and CAT-mimetic MI Intramyocardial injection [114] CuCe NPs SOD-and CAT-mimetic, copper chaperone MI Intramyocardial injection [115] Au-Se nanoparticles ROS-scavenging IR Intravenous injection [134] Cardiac patch (NO) NO delivery MI Intramyocardial administration [142] Fth-Cu NO generation MI Intravenous injection [147] ally, some targeted peptides, smart molecules, and antigens confer a specific ability to the nanomaterials to explicitly select the heart tissue. Thus, targeted nanomedicine is very effective, but fundamental research needs to translate into clinical application.…”

“…Recently, et al designed interesting Cu-deposited ceria nanoparticles (CuCe NPs) that exhibited multienzyme-mimetic activities and artificial chaperone function. [115] The ceria component of CuCe NPs displays SOD-and CAT-like abilities and detox-ifies ROS. In the mice MI model, the SOD1 activity is significantly enhanced after intramyocardial administration of CuCe NPs (0.5 mg kg −1 , around the infarction area, five times).…”

Advanced nanozymes possess peroxidase-like catalytic activities in biomedical and antibacterial fields: review and progress

“…12 SOD and CAT are two nanozymatic activities that can scavenge ROS and reactive nitrogen species (RNS) in a neutral environment, which are more often considered anti-inflammatory nanozymes to alleviate the oxidative stress suffered by the tissues. 13 OXD and POD activities, furthermore, are truly antimicrobial nanozymes, which catalyze specific substrates to produce highly toxic ROS that eliminate bacteria, addressing the source of the problem. However, the substrates of OXD nanozymes differ from POD.…”