Aim: To study clinical profile, laboratory features and importance of rehydration in patients admitted with acute kidney injury due to gastroenteritis. Materials and Methods: The study was carried out as a prospective observational study of 70 patients at medicine department of a medical college and tertiary health care center, over a period of two years that included cases of acute kidney injury due to gastroenteritis in the age group of 18-40 years. Results: Study showed male predominance (72.86%) in elderly age group. Prerenal type was more common (75.71%) as compared to acute tubular necrosis. Duration and frequency of diarrhea was associated with severity of the disease. Mortality was high (100%) in those who required more time (>12 hours) to achieve normal mean arterial pressure. Maximum deaths (93.33%) were observed in anuric patients. Most common complication observed was septicemia in 20% of patients. Overall mortality observed in our study was 21.43%, while 78.57% patients survived. Mortality was high in those having severe dehydration, high baseline creatinine, who received dialysis. Conclusion: Acute kidney injury due to gastroenteritis is preventable if presented early and adequate hydration can decrease mortality.
Background: Diabetes mellitus (DM) is a clinical syndrome characterized by hyperglycemia caused by relative or absolute deficiency of insulin 1. Cardiac autonomic neuropathy is a complication of diabetes. Our study intends to study Cardiac Autonomic Neuropathy in diabetics attending our hospital. Aims and Objectives: To study the clinical profile of Cardiac Autonomic Neuropathy in type 2 DM. Materials and Method: The study was carried out in a tertiary care hospital. The data was collected from August 2013 to December 2015 in 54 patients. The history, examination and bedside tests were done and conclusions drawn. Tests performed included heart rate response to deep breathing, standing, valsalva maneuver; BP response to sustained handgrip and standing. Results: Of 54 patients studied, 25 (46.29%) had CAN. Of the 25 patients affected with CAN 3 were between age 41-50, 10 between 51-60, 10 in 61-70 and 2 in 71-80. Out of 25 patients having CAN in the study 14 (56%) are male and 11 (44%) are female. Mean age of patients having CAN was 10.36 as compared to 6.55 in those not having CAN. Our study gave the following. Conclusions: Cardiac Autonomic Neuropathy is one of the most common but under diagnosed complications of diabetes mellitus. Cardiac Autonomic Neuropathy is associated with both type 1 and type 2 Diabetes Mellitus. It correlates with the duration and age. Resting tachycardia is a signs of autonomic dysfunction. Heart rate response to deep breathing and B.P. response to sustained hand grip are the most sensitive and specific tests for diagnosis of autonomic dysfunction. Cardiac Autonomic Neuropathy is significantly associated with other microvascular complications of DM like Diabetic retinopathy and nephropathy.
Background: To assess risk factors for coronary artery disease and their correlation with thyroid hormone profile amongst women with ST segment elevation in acute myocardial infarction. Method: A total number of 78 females having ST elevation myocardial infarction diagnosed through detailed clinical history and ECG evaluations were included after they satisfy the eligibility criteria. Patients were subsequently evaluated for presence of risk factors of ischemic heart disease such age, marital status, parity, and menopause, use of oral contraceptives, family history, obesity, diabetes mellitus, hypertension, hypercholesterolemia and hypertriglyceridemia. Their thyroid hormone profiles (T3, T4, TSH) were done and were correlated with risk factors for ischemic heart disease. Result: A total 78 patient included in the study. Most of the study population belongs to the age group of 40 to 50 years (43.6 %). Hypertension was the most common clinical features amongst study population (59%) followed by Diabetes (50%). most of the study population had Normal Thyroid status (57.69%) followed by Hypothyroidism (25.64%) and Hyperthyroidism (16.67%). and SERUM TSH is the most sensitive test for evaluation. Diabetes Mellitus was statistically significant risk factor (p value <0.05) in patients with STEMI with different levels of thyroid. Conclusion: Patients with coronary artery disease especially in the presence of other risk factors should be screened for diabetes and also for thyroid dysfunction as in our study cases of Hypothyroidism was seen in 25.64% of the population under study. Hence it can be postulated that hypothyroidism may be a predictor for myocardial injury in STEMI. Here we recommend that tests for thyroid disorders in acute coronary syndrome can give predictor for risk of morbidity and mortality in those subjects. These results also may warrant further larger study to investigate whether reversing the hypothyroidism could benefit the STEMI patients. Keywords: STEMI- ST segment elevation myocardial infarction, MI- Myocardial Infarction, Hyperthyroidism, Hypothyroidism, TSH- Thyroid Stimulating Hormone
Incidence of diabetes is increasing substantially worldwide. Cardiovascular disease is most prevalent cause of mortality and morbidity in diabetic populations. Cardiovascular risk factor including obesity, hypertension, dyslipidemia are common in patients with diabetes mellitus particularly with those of type 2 diabetes. Atherosclerosis has been described as an inflammatory disease. Aim: Study to evaluate correlation of C-Reactive Protein and Glycosylated Haemoglobin in Patients of Diabetes Suffering from Acute Coronary Syndrome. Material and Methods: A descriptive study after satisfying criteria was conducted in 115 patients in medicine department of a medical college and tertiary care hospital over a period of two years that included patients of diabetes suffering from acute coronary syndrome in the age group of 30 to 70 years. Evaluation and correlation was done by clinical profile. Results: Majority of patients were elderly age group of male of 51 to 60 yrs having mean BMI of 24 kg/m2. CRP level of >3 mg/dl was found in 77.39% and majority of patients had HbA1C >7%. CRP and HbA1C were significantly correlated (p<0.05). Majority of patients with elevated CRP were found in with killip class I. But CRP and killip classification were not significantly correlated in our study. Conclusion: Elevated C Reactive Protein and Glycosylated Haemoglobin are better correlated as poor prognostic marker for cardiovascular event in patients of diabetes suffering from acute coronary syndrome.
Aim: To study the clinical profile of diabetic patients who present with Acute Coronary Syndrome (ACS) for the first time, to correlate the Blood Sugar Level (BSL) and Glycosylated hemoglobin (HbA 1C ) at the time of admission and the severity of acute coronary syndrome; and to assess the correlation between tight glycemic control of diabetics based on HbA 1C estimation and presence of end organ damage in diabetics. Materials and Methods: The study was undertaken at our medical college in the medicine department. 64 adult patients who are known diabetics or detected for the first time presenting in outpatient department or emergency department as acute coronary syndrome were studied. Study period was 2 years from January 2011 to December 2012. Results: The study showed a definite male preponderance, with 56.23% males as compared to 43.73% females. Atypical presentations of acute coronary syndrome were more common as compared to typical chest pain (34.37%). Chest pain commonly is prevalent in younger age group. 95.30% of the patient had some or other associated risk factors like hypertension (59.37%), smoking (26.56%), obesity (15.62%) or dyslipidemia (65.62%). ST elevation MI was the commonest presentation (73.40%) and involvement of anterior wall was common (36.20%). On admission BSL (Blood Sugar Level) was not found to have a definite prognostic value in predicting outcome in diabetic patients with acute coronary syndrome. Impaired glycosylated haemoglobin was found to be an independent risk factor and had a definite prognostic value in predicting outcome. Diabetic patient with acute coronary syndrome had LV dysfunction, cardiac rhythm abnormalities, cardiogenic shock and are likely to be readmitted, thus having worst morbidity as well as mortality. Conclusion: The primary aim of this study was to study correlation of blood sugar level and glycosylated haemoglobin at the time of admission with severity of acute coronary syndrome and to study clinical profile of diabetic patients with due consideration to complications which are related to diabetes.
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