Summary
In previous studies, the authors have shown that successful modular construction depends on using the correct types of joint connections. In this experimental study, steel beam–column joint connections were shown to be very efficient in facilitating the construction of modular frames while ensuring sufficient flexural moment capacity at the joints to resist lateral loads. This research also included an investigation of the behavior, the crack pattern, and the flexural moment capacity of concrete columns with hybrid composite joints by means of structural experiments on three specimens. Three column specimens were subjected to cyclic loading under displacement control using an oil jack. The influence of including steel sections at the beam–column joint upon the flexural moment capacity of the column was studied, and the use of concrete–steel hybrid composite joints was found to increase the flexural structural performance of the concrete columns. The flexural moment capacity in the maximum load limit state of a concrete column with steel joints was 43.2% greater than that of a conventional reinforced concrete column without steel joints. The steel section in the joint was found to greatly contribute to the flexural moment capacity and to the modular construction technologies.
The categorization of neurodegenerative diseases has evolved based on advances in genetic, molecular and pathological research. In many neurodegenerative diseases, aggregation of a misfolded protein is responsible for the development of pathologic inclusions. When the misfolded protein is tau or synuclein, these diseases are called tauopathies or synucleinopathies, respectively. This article focuses on ophthalmic findings in some of the most common tauopathies and synucleinopathies: Alzheimer's disease, progressive supranuclear palsy, Parkinson's disease, dementia with Lewy bodies and multisystem atrophy.
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