This paper describes results of two ecological studies design to analyze the incidence of selected malignancies in two populations exposed to polychlorinated hydrocarbons, mostly PCBs and TCDDs/Fs by comparing data available in the National Cancer Registry of the Slovak Republic and National Oncological Registry of the Czech Republic databases for the Slovak Republic (approximately 5M inhabitants) and the Czech Republic (10,3 M inhabitants) to the data relevant for the population of Michalovce District, the Slovak Republic (approximately 112,000 inhabitants) and Uherske Hradiste, the Czech Republic (146,000 inhabitants). Those districts are recognized as PCB-contaminated areas due to production and industrial use of PCBs. Data were analyzed for the 10-year period 1987-1996. The age adjusted world standard ratio (WSR) incidence of thyroid, pancreatic, breast, ovarian, bladder, and brain tumors in females and thyroid, pancreatic, breast, bladder, brain, prostate and testicular tumors in males were compared. Neither PCBs nor TCDDs/Fs appear to contribute to the observed significantly lower incidence of breast and prostate cancer in the Michalovce District and lower bladder cancer incidence in Uherske Hradiste District. However, anti-estrogenic and anti-androgenic properties have been described for hydroxylated and methylsulfonyl PCB metabolites. These properties could contribute to a mechanism through which these metabolites might modulate the development of breast, prostate and bladder cancer. The results of our analysis points to substantial potential problems of risk assessment for cancer incidence in populations exposed to xenobiotics, or more generally, as it relates to a wide spectrum of confoundings of cancer risk factors.
Objective: To describe feeding patterns during first two years of life and their relation to sociodemographic factors. Design: Longitudinal study. Setting: Prague, Czech Republic. Subjects: Ninety-seven full-term healthy singletons enrolled at maternity ward, of which 90.7% completed the study. Methods: Diet was assessed at 9, 12 and 24 months of age using a structured 3-day dietary record. Additional information was obtained from questionnaires completed at birth and at 6 months. Results: The median duration of exclusive breastfeeding was 5 months, and that of total breastfeeding 9 months. Breastfeeding rate 47.4% at 9 months declined to 4.5% at 24 months. Total duration of breastfeeding was positively associated with maternal education and marital status but not with maternal age, gender or birth order. Breastfeeding frequency at 9, 12 and 24 months was 4.8, 4 and 3.7, respectively. The complementary food feeding frequency increased significantly with age (4.5, 4.7 and 5.9 times per day, respectively). All children at any age point consumed fruits, cereal and milk products. The proportion of children consuming meat and vegetables had increased with age but between ages 9 and 24 months, at least 23-38% children did not consume vegetables daily and 28-40% did not consume foods from meat/fish/poultry/eggs group daily. The proportion of children consuming milk and foods associated with the early complementary feeding period had fallen with age while the consumption of cereal foods other than porridge had increased. Values of indicators of adequate complementary feeding practices tentatively suggested in the context of WHO expert consultation had closely reflected breastfeeding rates. Conclusions: Breastfeeding duration is shorter than WHO recommends. It is influenced by maternal education and marital status. Compliance with complementary feeding recommendations is relatively good. Continued promotion of healthy infant and young child feeding practices is needed. Indicators evaluating complementary feeding practices should assess breastfeeding separately from other aspects.
The subject of the study was the ecological and human health consequences of environmental pollution from emissions arising from burning local coal with an arsenic content ranging from 900 to 1,500 g/tonne of dry substance. The first indication of environmental pollution by arsenic-containing emissions was the mass extinction of honeybee colonies. The neurotoxic and carcinogenic aspects of arsenic exposure were followed. On using a group diagnostics approach, significant hearing losses were detected in exposed children in both air and bone conduction audiometry at high frequency range (4,000 and 8,000 Hz, respectively). Exposure assessment of the local population of the Prievidza district, Central Slovakia, was based on biological monitoring. The criterion of higher exposure was arsenic content in hair exceeding concentrations of 3 microg/g of hair. In a 7.5-km radius of the exposed region, live about two-tenths of the district population who were considered as "exposed" and rest of the district served as the "reference" population. The subject of our analysis was a database of 1,503 non-melanoma skin cancer (NMSC) cases (756 in men and 747 in women) collected from 1977 to 1996 in the Prievidza district, Central Slovakia (population approximately 125,000). The age standardized incidence of NMSC (each confirmed by histological examination) in non-occupational settings ranged from 45.9 to 93.9 in men and from 34.6 to 81.4 in women. Analysis of our data demonstrates a positive correlation between human cumulative exposure to arsenic and incidence of NMSC.
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