Non‐melanoma Skin and Lung Cancer Incidence in Relation to Arsenic Exposure: 20 Years of Observation

Bencko, Vladimír; Franěk, Petr; Rameš, Jiří; Fabiánová, Elenóra; Götzl, Miloslav

doi:10.1002/0470857706.ch24

Cited by 5 publications

(4 citation statements)

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“…In the second half of the 1970s, carefully performed epidemiological studies emerged, confirming previously demonstrated causal relationships between non-melanoma skin cancer and exposure to inorganic arsenic, characterized by the multifocal lesions mentioned above (Ishinishi et al 1986;Tseng 1977;Tsuchiya 1977;Borgono et al 1977), which were followed by later studies (e.g., Luchtrath 1983;Pleško et al 2000;Bencko et al 2005). Skin is the most exposed organ while spraying the pesticide on fields (Thiers et al 1967).…”

Section: Carcinogenicity Potentialmentioning

confidence: 54%

Best practices for promoting farmers’ health: the case of arsenic history

Bencko

Slámová

2007

J Public Health

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Section: Carcinogenicity Potentialmentioning

confidence: 54%

Best practices for promoting farmers’ health: the case of arsenic history

Bencko

Slámová

2007

J Public Health

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“…Quoted from Bencko et al (2005) after meta-analysis of our database 1977-1981 1982-1986 1987-1991 1992-1996 We feel strongly that the downward trend in the incidence of NMSC following reduction in the arsenic emissions from the power plant may suggest a dose-eVect relationship between the degree of environmental pollution due to arsenic and NMSC incidence.…”

Section: Resultsmentioning

confidence: 96%

“…In our opinion, this downward trend in the incidence of NMSC is most likely Table 1 Non-melanoma skin cancer incidence in population living in the vicinity of the power-plant burning the coal of high arsenic content and in the rest of the district (males only) Quoted from Bencko et al (2005) after meta-analysis of our database 1977-1981 1982-1986 1987-1991 1992-1996 Table 2 Non-melanoma skin cancer incidence in population living in the vicinity of the power-plant burning the coal of high arsenic content and in the rest of the district (females only)…”

Section: Resultsmentioning

confidence: 99%

Ecological and human health risk aspects of burning arsenic-rich coal

Bencko

Rameš

Fabiánovà

et al. 2008

Environ Geochem Health

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The subject of the study was the ecological and human health consequences of environmental pollution from emissions arising from burning local coal with an arsenic content ranging from 900 to 1,500 g/tonne of dry substance. The first indication of environmental pollution by arsenic-containing emissions was the mass extinction of honeybee colonies. The neurotoxic and carcinogenic aspects of arsenic exposure were followed. On using a group diagnostics approach, significant hearing losses were detected in exposed children in both air and bone conduction audiometry at high frequency range (4,000 and 8,000 Hz, respectively). Exposure assessment of the local population of the Prievidza district, Central Slovakia, was based on biological monitoring. The criterion of higher exposure was arsenic content in hair exceeding concentrations of 3 microg/g of hair. In a 7.5-km radius of the exposed region, live about two-tenths of the district population who were considered as "exposed" and rest of the district served as the "reference" population. The subject of our analysis was a database of 1,503 non-melanoma skin cancer (NMSC) cases (756 in men and 747 in women) collected from 1977 to 1996 in the Prievidza district, Central Slovakia (population approximately 125,000). The age standardized incidence of NMSC (each confirmed by histological examination) in non-occupational settings ranged from 45.9 to 93.9 in men and from 34.6 to 81.4 in women. Analysis of our data demonstrates a positive correlation between human cumulative exposure to arsenic and incidence of NMSC.

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“…Pesch et al (2002) reported an increase in nonmelanoma skin cancers resulting from exposure from a Slovakian coal-burning power plant, but exposure levels associated with the lesions were not presented. Bencko et al (2005) also reported an increase in the incidence of nonmelanoma skin cancer among workers of a power plant burning coal of a high arsenic content and in the population living in the vicinity of the power plant. Bulbulyan et al (1996) reported an increase in risk of stomach cancer among workers exposed to the highest average arsenic concentrations at a Russian fertilizer plant, but this finding, which was based on a small number of observations and was only marginally statistically significant, was confounded by exposure to nitrogen oxides, which were more convincingly associated with stomach cancer in this study.…”

Section: Cancermentioning

confidence: 89%