A palladium-catalyzed
asymmetric tandem [3+2] cycloaddition/allylation of methylene-trimethylenemethane
is presented, providing the functionalized chiral hexahydropyrazolo[5,1-a]isoquinoline derivatives in high yields with good to excellent
enantioselectivities and moderate to good E:Z ratios. In the one-pot sequential tandem reactions/hydroxylation,
(E)-allylic alcohol products were obtained in good
yields with excellent enantioselectivities.
A phosphine-catalyzed
[3 + 2] annulation of Morita–Baylis–Hillman
(MBH) carbonates with 3-methyl-4-nitro-5-styrylisoxazoles has been
developed to afford various multifunctional isoxazoles in moderate
to good yields with moderate to excellent diastereoselectivities.
With a spirocyclic chiral phosphine as the catalyst, up to 89% ee
was obtained.
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