“…Cycloaddition reactions are one of the most frequented classes of reactions in organic chemistry. In synthetic chemistry, isatin has a highly reactive C-3 carbonyl group and complex multi-spiro-heterocycles can be constructed by implying 1,3-dipolar cycloaddition reactions ( Borad et al, 2014 ; Zhu et al, 2017 ; Dwivedi et al, 2021 ), Morita–Baylis–Hillman reaction ( Deng et al, 2011 ; Liao et al, 2021 ), electrocyclization ( Viswambharan et al, 2010 ), and photo-induced reactions ( Wang et al, 2005 ). The 1,3-dipolar cycloaddition reactions (1,3-DCR) are a fascinating set of protocols that are often regarded as the most competent process and opens new vistas in the field of furnishing efficient and high-yield products in a regio- and stereo-controlled fashion ( Coldham and Hufton, 2005 ; Ramesh et al, 2018 ; Reddy et al, 2018a ; Reddy et al, 2018b ; Kumar et al, 2019 ; ).…”