Rocksalt CoO nanoparticles (CNPs) have been prepared with a facile solvothermal method. To control the magnetism of CNPs, the reduced graphene oxide (RGO) is adopted to engineer the CNPs. Enwrapped by the atomic-layered carbon sheets, the CNPs can be reduced locally. The CoO/RGO composites were prepared by one-pot and two-pot synthetic methods, respectively. Compared with the CoO/RGO raw composite that have no magnetization hysteresis loop, the weak and the strong hysteresis loops emerged successively via heating the particles at different temperatures and maintaining their nanoscales. The magnetism can be adjusted by controlling the temperature via two routes. By the one-pot synthetic route, the CNPs can be reduced sharply, and an obvious hysteresis is available around 400 °C, which is ascribed to the appearance of Co nanoclusters decorated in the corners of CNPs. By the two-pot synthetic route, a weak and gradually enhanced hysteresis can be observed, and its magnetic properties should be ascribed to the topological defects of RGO. Our findings have opened a new way to acquire nanoparticles with controllable magnetism.
Recent studies have confirmed the existence of microbiota in the lungs. The relationship between lung ground-glass opacity (GGO) and microbiota in the lung microenvironment is not clear. In this study, we investigated the microbial composition and diversity in bronchoalveolar lavage fluid (BALF) of diseased lung segments and paired contralateral healthy lung segments from 11 GGO patients. Furthermore, lung GGO and paired normal tissues of 26 GGO patients were explored whether there are microbial characteristics related to GGO. Compared with the control group, the community richness of GGO tissue and BALF of GGO lung segment (α-diversity) and overall microbiome difference (β-diversity) had no significant difference. The microbiome composition of BALF of GGO segments is distinct from that of paired healthy lung segments [genus (Rothia), order (Lachnospiraceae), family (Lachnospiraceae), genus (Lachnospiraceae_NK4A136_group, Faecalibacterium), and species (Faecalibacterium prausnitzii, Bacteroides uniforms)]. GGO tissue and adjacent lung tissue had more significant differences at the levels of class, order, family, genus, and species level, and most of them are enriched in normal lung tissue. The area under the curve (AUC) using 10 genera-based biomarkers to predict GGO was 91.05% (95% CI: 81.93–100%). In conclusion, this study demonstrates there are significant differences in the lower respiratory tract and lung microbiome between GGO and the non-malignant control group through the BALF and lung tissues. Furthermore, some potential bacterial biomarkers showed good performance to predict GGO.
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