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The Einstein Gravity Explorer mission (EGE) is devoted to a precise measurement of the properties of space-time using atomic clocks. It tests one of the most fundamental predictions of Einstein's Theory of General Relativity, the gravitational redshift, and thereby searches for hints of quantum effects in gravity, exploring one of the most important and challenging frontiers in fundamental physics. The primary mission goal is the measurement of the gravitational redshift with an accuracy up to a factor 10 4 higher than the best current result. The mission is based on a satellite carrying cold atombased clocks. The payload includes a cesium microwave clock (PHARAO), an optical clock, a femtosecond frequency comb, as well as precise microwave time transfer systems between space and ground. The tick rates of the clocks are continuously compared with each other, and nearly continuously with clocks on earth, during the course of the 3-year mission. The highly elliptic orbit of the satellite is optimized for the scientific goals, providing a large variation in the gravitational potential between perigee and apogee. Besides the fundamental physics results, as secondary goals EGE will establish a global

Understanding the relationship between brain activity and specific mental function is important for medical diagnosis of brain symptoms, such as epilepsy. Magnetoencephalography (MEG), which uses an array of high-sensitivity magnetometers to record magnetic field signals generated from neural currents occurring naturally in the brain, is a noninvasive method for locating the brain activities. The MEG is normally performed in a magnetically shielded room. Here, we introduce an unshielded MEG system based on optically pumped atomic magnetometers. We build an atomic magnetic gradiometer, together with feedback methods, to reduce the environment magnetic field noise. We successfully observe the alpha rhythm signals related to closed eyes and clear auditory evoked field signals in unshielded Earth’s field. Combined with improvements in the miniaturization of the atomic magnetometer, our method is promising to realize a practical wearable and movable unshielded MEG system and bring new insights into medical diagnosis of brain symptoms.

sion, peritumoral enhancement, and other imaging features have been reported as predictors in HCC for MVI or posthepatectomy recurrence HCC [5][6][7]. However, independent validation of these features has not yet been performed, and these features are not yet applied widely.The Liver Imaging Reporting and Data System (LI-RADS) [8] was developed to standardized terminology, interpretation, and reporting of imaging for HCC diagnosis. The system addresses the full spectrum of liver lesions and pseudolesions with a 5-point scale reflecting the relative likelihood of HCC, from LR-1 (definitely benign) to LR-5 ( definitely HCC). LI-RADS also assigns category LR-M to observations considered probably or definitely malignant but lacking criteria specific for HCC and a separate category (LR-TIV

Numerous efficient synthetic methods for enantioselective indole functionalizations have emerged in recent years. This review summarizes the major achievements in the transition-metal-catalyzed enantioselective indole functionalization reactions since 2010 and focuses on C-C bond formation processes, including alkylations, arylations, cycloaddition reactions, and other reactions. It intends to give a compendious overview of the significant progress achieved in this area.

We demonstrate an external-cavity laser system using an anti-reflection coated laser diode as gain medium with about 60 nm fluorescence spectrum, and a Rb Faraday anomalous dispersion optical filter (FADOF) as frequency-selecting element with a transmission bandwidth of 1.3 GHz. With 6.4% optical feedback, a single stable longitudinal mode is obtained with a linewidth of 69 kHz. The wavelength of this laser is operating within the center of the highest transmission peak of FADOF over a diode current range from 55 mA to 142 mA and a diode temperature range from 15 °C to 35 °C, thus it is immune to the fluctuations of current and temperature.

Liver fibrosis, as one of the leading causes of liver‐related morbidity and mortality, has no Food and Drug Administration (FDA)‐approved antifibrotic therapy yet. Although microRNA‐29b (miRNA‐29b) and microRNA‐122 (miRNA‐122) have great potential in treating liver fibrosis via regulating profibrotic genes in hepatic stellate cells (HSCs), it is still a challenge to achieve a HSC‐targeted and meanwhile noninvasively trackable delivery of miRNAs in vivo. Herein, a pH‐sensitive and vitamin A (VA)‐conjugated copolymer VA–polyethylene glycol–polyethyleneimine–poly( N ‐( N ′, N ′‐diisopropylaminoethyl)‐ co ‐benzylamino) aspartamide (T‐PBP) is synthesized and assembled into superparamagnetic iron oxide (SPIO)‐decorated cationic micelle for miRNA delivery. The T‐PBP micelle efficiently transports the miRNA‐29b and miRNA‐122 to HSC in a magnetic resonance imaging‐visible manner, resulting in a synergistic antifibrosis effect via downregulating the expression of fibrosis‐related genes, including collagen type I alpha 1, α‐smooth muscle actin, and tissue inhibitor of metalloproteinase 1. Consequently, the HSC‐targeted combination therapy with miRNA‐29b and miRNA‐122 demonstrates a prominent antifibrotic efficacy in terms of improving liver function and relieving hepatic fibrosis.

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