[1] Same beam very long baseline interferometry (VLBI) observations of the two subsatellites of SELENE (KAGUYA) are demonstrated for purpose of the precise gravimetry of the Moon. Same beam VLBI contributes a great deal to cancel out the tropospheric and ionospheric delays and to determine the absolute value of the cycle ambiguity by using the multifrequency VLBI method. As a result, the differential phase delay of the X-band signal is estimated within an error of below 1 ps. This accuracy is more than 1 order of magnitude smaller than former VLBI results. The preliminary results for the orbit determination of the subsatellites show a decrease of the orbit error from a few hundreds of meters to around 10 m when the differential phase delay data are added to the conventional range and Doppler data. These results reveal the possibility of precise gravimetry.Citation: Kikuchi, F., et al. (2009), Picosecond accuracy VLBI of the two subsatellites of SELENE (KAGUYA) using multifrequency and same beam methods, Radio Sci., 44, RS2008,
Objective
Helicobacter pylori
(
H. pylori
) infection is closely associated with gastric ulcers and gastric adenocarcinomas. We aimed to assess the efficacy and safety of a quadruple regimen with amoxicillin plus berberine vs tetracycline plus furazolidone in rescue therapy for
H. pylori
eradication.
Methods
We conducted a randomized, open‐label, multicenter, noninferiority trial. Patients with previous treatment failures recruited from five centers were randomized (1:1) to receive a regimen with esomeprazole and bismuth plus either berberine and amoxicillin (the BA group) or tetracycline and furazolidone (the TF group) for 14 days. Their
H. pylori
infection status was confirmed 4‐8 weeks after treatment. The primary outcome was the eradication rate. The secondary outcomes included the rates of symptom improvement, compliance, and adverse events. This study was registered at
ClinicalTrials.gov
(NCT03609892).
Results
Altogether 658 participants were consecutively enrolled. An intention‐to‐treat analysis demonstrated that the two regimens achieved a similar eradication rate (76.3% vs 77.5%;
P
= 0.781). The per‐protocol analysis reached a similar result (81.5% vs 85.0%;
P
= 0.278). The eradication rate reached in the BA group was greater than the pre‐established margin of noninferiority, at −10% (the lower bounds of the 95% CI were −7.66% and −9.43%, respectively). The rate of adverse events was lower for the BA group than the TF group (18.5% vs 26.1%,
P
= 0.024). Rates of compliance and symptom improvement were similar for the two therapies.
Conclusion
The efficacy of both regimens in rescue treatment for
H. pylori
eradication was satisfactory, 14‐day BA‐based quadruple therapy is noninferior to the TF‐based therapy.
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