No abstract

No abstract

The contribution of epigenetic mechanisms as a potential treatment model has been observed in cancer and autoimmune/inflammatory diseases. This review aims to put forward the epigenetic mechanisms as a promising strategy in implant surface functionalization and modification of biomaterials, to promote better osseointegration and bone regeneration, and could be applicable for alveolar bone regeneration and osseointegration in the future. Materials and Methods: Electronic and manual searches of the literature in PubMed, MEDLINE, and EMBASE were conducted, using a specific search strategy limited to publications in the last 5 years to identify preclinical studies in order to address the following focused questions: (i) Which, if any, are the epigenetic mechanisms used to functionalize implant surfaces to achieve better osseointegration? (ii) Which, if any, are the epigenetic mechanisms used to functionalize biomaterials to achieve better bone regeneration? Results: Findings from several studies have emphasized the role of miRNAs in functionalizing implants surfaces and biomaterials to promote osseointegration and bone regeneration, respectively. However, there are scarce data on the role of DNA methylation and histone modifications for these specific applications, despite being commonly applied in cancer research. Conclusions: Studies over the past few years have demonstrated that biomaterials are immunomodulatory rather than inert materials. In this context, epigenetics can act as next generation of advanced treatment tools for future regenerative techniques. Yet, there is a need to evaluate the efficacy/cost effectiveness of these techniques in comparison to current standards of care.

This paper proposes an isolated hybrid system consisting of a solar photovoltaic (SPV) panel along with a diesel engine driven permanent magnet synchronous generator (PMSG) and a battery energy storage system (BESS) feeding three-phase four wire loads. The deployment of this microgrid system is to maximize utilization of renewable resources for energy security and improved power quality. The incremental conductance (InC) maximum power point tracking (MPPT) algorithm is applied for extracting the maximum power of the SPV panel. The controller makes use of the enhanced phase locked loop (EPLL) technique and is shown to provide for load balancing, reactive power compensation and harmonics compensation capabilities under different loading conditions. A four-leg voltage source converter (VSC) with BESS further provides neutral current compensation apart from coordinating power flow within the autonomous system. Performance of the controller has been analyzed by modeling the system in MATLAB/SIMULINK using sim-power system (SPS) block-set.

No abstract

This paper proposes a systematic control for a solar photo-voltaic (SPV) array, diesel generator (DG) and battery energy storage (BES) integrated microgrid system. This system intends to utilize the maximum SPV power using the maximum power point tracking (MPPT) controller under varying operating conditions. It maintains the power balance with the provision of catering the load requirement by providing charging and discharging of the battery and provide an optimal operation of DG. The peak detection control technique is deployed for the management of power between the distributed energy sources. The control method together with three leg voltage source converter (VSC) allows reactive power compensation, harmonics elimination and voltage regulation at the point of common coupling (PCC).The frequency of the system is maintained through a DG set. The detailed analysis is conducted by modelling this system using sim power system (SPS) toolbox in Matlab/Simulink and the performance of the system is validated using simulation results.

No abstract

No abstract