Person re-identification (ReID) has achieved significant improvement under the single-domain setting. However, directly exploiting a model to new domains is always faced with huge performance drop, and adapting the model to new domains without target-domain identity labels is still challenging. In this paper, we address cross-domain ReID and make contributions for both model generalization and adaptation. First, we propose Part Aligned Pooling (PAP) that brings significant improvement for cross-domain testing. Second, we design a Part Segmentation (PS) constraint over ReID feature to enhance alignment and improve model generalization. Finally, we show that applying our PS constraint to unlabeled target domain images serves as effective domain adaptation. We conduct extensive experiments between three large datasets, Market1501, CUHK03 and DukeMTMC-reID. Our model achieves state-of-the-art performance under both source-domain and cross-domain settings. For completeness, we also demonstrate the complementarity of our model to existing domain adaptation methods. The code is available at https://github.com/ huanghoujing/EANet.
The present study aimed to examine the potential inhibitory activity of oleoylethanolamide (OEA) on α-melanocyte stimulating hormone (α-MSH)-stimulated melanogenesis and the molecular mechanism(s) involved in the process in B16 mouse melanoma cells. Our data demonstrated that OEA markedly inhibited melanin synthesis and tyrosinase activity in α-MSH-stimulated B16 cells. In addition, the expression of melanogenesis-related proteins, such as melanocortin-1 receptor (MC1R), microphthalmia-associated transcription factor (MITF), tyrosinase-related protein-1 (TRP-1) and tyrosinase, was suppressed in a concentration-dependent manner by OEA. In addition, OEA may suppress melanogenesis through a peroxisome proliferator-activated receptor α (PPARα)-independent pathway. Moreover, OEA activated ERK, Akt, p38 pathways and inhibits CREB pathway in α-MSH-stimulated B16 cells. The specific ERK inhibitor PD98059 partly blocked OEA-inhibited melanin synthesis and tyrosinase activity and partly abrogated the OEA-suppressed expression of melanogenic proteins. Furthermore, OEA presented remarkable inhibition on the body pigmentation in the zebrafish model system. Our findings demonstrated that OEA is an effective inhibitor of hyperpigmentation through activation of ERK, Akt and p38 pathways, inhibition of the CREB pathway, and subsequent down-regulation of MITF, TRP-1 and tyrosinase production.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.