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The restriction of an individual’s daily life due to the strengthening of quarantine and lockdown increases psychosocial stress. This study aimed to determine the factors that influence psychosocial stress during a period of strict quarantine and lockdown to curb the COVID-19 pandemic in Korea. A total of 338 adults participated in a cross-sectional online survey conducted from 19–25 May 2020, which measured knowledge of COVID-19, health belief, resilience, and psychosocial stress. According to the results, there was no difference between the participants’ scores from the Daegu area (with concentrated confirmed COVID-19 cases) and the non-Daegu area except for health belief. Eighty-two percent of participants constituted the high-risk group for psychosocial stress. Individual resilience was positively correlated with health belief and negatively correlated with psychosocial stress (p < 0.001). Further, the following factors affected the level of psychosocial stress: resilience, subjective health status, and monthly household income, with an explanatory power of 39.8%. Therefore, those with higher subjective health and higher monthly household income experienced higher psychosocial stress, whereas higher resilience indicated lower psychosocial stress.

(1) Background and Objectives: There were two distinct coronavirus disease 2019 (COVID-19) outbreaks in 2020 and 2022 at a long-term mental health facility (LTMHF) in Gyeonggi Province, Korea. We aimed to compare the two outbreaks and identify differences in epidemiological and clinical outcomes due to changes in epidemic timing and management methods. (2) Materials and Methods: The structural, operational, and case-specific LTMHF data of COVID-19-confirmed patients during these outbreaks in 2020 and 2022 were retrospectively analyzed. (3) Results: Forty individuals (37 residents) in 2020 and thirty-nine (32 residents) in 2022 were confirmed to have COVID-19, and ten were infected twice. Facility isolation was implemented as an infection control measure, and one COVID-19-related death occurred in 2020. All residents and staff were vaccinated at least twice in 2022; moreover, in 2022, 38 patients (97.4%) received a third vaccination less than months before infection. The average Ct value of the cases in 2022 was significantly higher than that in 2020; however, vaccine-breakthrough (V-BT) and reinfection after vaccination rates were similar. (4) Conclusions: COVID-19 vaccination could help lower the viral load of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was inversely correlated with Ct values, and ventilation system improvements in health facilities might reduce transmissibility.