Objective: To study the pathogen distribution, antimicrobial susceptibility and risk factors of postoperative nosocomial infections among children with congenital heart disease.
Methods: Three hundreds children with congenital heart disease admitted to our hospital to receive surgeries from February 2010 to February 2013 were selected.
Results: A total of 120 children were tested as positive by sputum culture, with the infection rate of 40.0%. The top five most common pathogenic microorganisms included Staphylococcus epidermidis, Staphylococcus aureus, Enterococcus, Pseudomonas aeruginosa, and Candida albicans. S. epidermidis, S. aureus and Enterococcus were highly resistant to penicillin, azithromycin and erythromycin, moderately susceptible to levofloxacin and cefazolin, and completely susceptible to vancomycin. Multivariate Logistic regression analysis showed that hospitalization stay length, combined use of antibiotics, systemic use of hormones, mechanical ventilation and catheter indwelling were the independent risk factors of postoperative nosocomial infections (P<0.05).
Conclusion: Nosocomial infection, which was the most frequent postoperative complication of pediatric congenital heart disease, was predominantly induced by Gram-positive bacteria that were highly susceptible to cephalosporins and vancomycin. Particular attention should be paid to decrease relevant risk factors to improve the prognosis.
Previously, there is no study looking at serum biomarkers for epilepsy. Epilepsy can trigger neuroinflammation events, and serum amyloid A (SAA) is one biomarker as acute-phase protein in multiple diseases. In present study, we detected serum SAA peak in epileptic patients with mass spectrometry and quantified with enzyme-linked immunosorbent assay measurement. The results suggested that in acute phase of epilepsy, the serum SAA increased, but after 3 months of treatment, the SAA peak was disappeared. In conclusion, the study provided values of proteomic diagnosis of epilepsy.
In the crystal structure of the title compound, C10H11NO5, intermolecular O—H⋯O hydrogen bonds link the molecules into chains along the b-axis direction. Weak C—H.·O hydrogen bonds also occur.
Key indicators: single-crystal X-ray study; T = 293 K; mean (C-C) = 0.004 Å; disorder in main residue; R factor = 0.078; wR factor = 0.233; data-to-parameter ratio = 11.6.The chlorophenyl group of the title compound, C 18 H 12 ClNO 4 , is disordered over two orientations with occupancies of 0.331 (8) and 0.669 (8). An intramolecular hydrogen bond is formed between a hydroxy group and the acyclic carbonyl group. In the crystal, molecules are linked into chains along [110] by O-HÁ Á ÁO and C-HÁ Á ÁO hydrogen bonds, forming a ladder motif.
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