Human serum amyloid A (SAA) protein changes in acute epilepsy patients

Li, Guifen; Ren, Fang; Yao, Jin-Hua; Wang, Mingying; Feng, Xing; Liu, Dong

doi:10.3109/00207454.2012.756876

Cited by 6 publications

(5 citation statements)

References 12 publications

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“…Moreover, mRNA expression of SAA showed increase in women who used finasteride in comparison with the normal levels in control group. Thus, up-regulated expression of SAA levels could be a cause of uterine bleeding [9,11,12] and as a result of irregular uterine bleeding for prolonged periods [9,12]. The mRNA expression profiling was also validated using hierarchical clustering that revealed the effect of finasteride in women for long-term treatment.…”

Section: Discussionmentioning

confidence: 99%

“…The SAA is the common serum biomarker of dysfunctional uterine bleeding. The properties and biological functions of angiogenic growth factors such as VEGF and VKOR have been demonstrated in several studies [9][10][11][12]. Testosterone, which is the main circulating androgen, must be converted into dihydrotestosterone by the 5α-reductase enzyme as shown in Figure 1 [13].…”

Section: Introductionmentioning

confidence: 97%

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Prolonged use of finasteride-induced gonadal sex steroids alterations, DNA damage and menstrual bleeding in women

Albasher¹,

Bin-Jumah

Al‐Farraj

et al. 2020

Bioscience Reports

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The aim of the present study was to examine the effect of prolonged use of finasteride on serum levels of dihydrotestosterone (DHT), estradiol (E2), progesterone, testosterone and androstenedione in women during the menstrual period. Further, to screen and compare the 5α-reductase activities through the expression of SRD5A1, SRD5A2 and AR gene and to determine the level of VEGF, VKOR and SAA gene expression and DNA damage. A total of 30 Saudi women aged between 25 and 35 years were enrolled in the study. The selected women were divided into two groups. The first group (n = 15) received 5 mg finasteride/day for prolonged period of one year and second group (n = 15) was taken as a healthy control. ELISA technique was used for measuring the serum levels of the targeted hormones, and Comet assay was used for checking the DNA integrity. Our findings revealed significant decrement of DHT, E2, progesterone and androstenedione levels and elevated levels of testosterone in group treated with daily oral doses of 5 mg finasteride/day compared with the control subjects. mRNA expression suggested that finasteride has concrete effects on the gene expression of the selected genes from the treated group in comparison with the control group. In addition, finasteride induced DNA damage, and heavy menstrual bleeding was noted in women treated with finasteride. In conclusion, the present findings revealed that finasteride has adverse health effects in women associated with gonadal sex steroids alterations, DNA damage and heavy menstrual bleeding with no consensus in the treatment of androgenetic alopecia in women.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

Prolonged use of finasteride-induced gonadal sex steroids alterations, DNA damage and menstrual bleeding in women

Albasher¹,

Bin-Jumah

Al‐Farraj

et al. 2020

Bioscience Reports

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“…Li et al 26 have used mass spectrometry for detection of proteins in serum samples, and ELISA measurements for quantication. They detected the biomarker SAA.…”

Section: Sample Preparations In Proteomicsmentioning

confidence: 99%

Recent developments in proteomic methods and disease biomarkers

Bergman

Bergquist

2014

Analyst

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Proteomic methodologies for identification and analysis of biomarkers have gained more attention during recent years and have evolved rapidly. Identification and detection of disease biomarkers are important to foresee outbreaks of certain diseases thereby avoiding surgery and other invasive and expensive medical treatments for patients. Thus, more research into discovering new biomarkers and new methods for faster and more accurate detection is needed. It is often difficult to detect and measure biomarkers because of their low concentrations and the complexity of their respective matrices. Therefore it is hard to find and validate methods for accurate screening methods suitable for clinical use. The most recent developments during the last three years and also some historical considerations of proteomic methodologies for identification and validation of disease biomarkers are presented in this review.

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“…2 Previous studies suggested that certain diseases such as rheumatic disorders (rheumatoid arthritis, ankylosing spondylitis), major depression, auto inflammatory diseases (familial Mediterranean fever, Hashimoto's thyroiditis), diabetes mellitus, systemic lupus erythematosus, acute pancreatitis, inflammatory bowel diseases, psoriasis, several types of vasculitis, and epilepsy affect SAA levels. 3,4 In addition to above diseases, statins, glucocorticoids, corticosteroids, disease-modifying antirheumatic drugs, and nonsteroidal anti-inflammatory drugs could alter SAA levels. 5,6 Also, dietary supplements such as vitamin A, vitamin E, antioxidants (ascorbic acid, taurine, phytic acid), omega-3 fatty acids, a linoleic acid, and polyunsaturated fatty acids can influence SAA levels.…”

mentioning

confidence: 99%