A dose\p=n-\responserelationship was observed in the percentage of morphologically abnormal spermatozoa as a function of age for 2-, 6-, 12-, 18-and 25-month-old C57BL/6 male mice. Compared with values for younger mice, 25-month-old mice had a significantly (P < 0\m=.\005)higher percentage of abnormal spermatozoa (23\m=.\9\ m=+-\ 2\m=.\3%)and the percentages in mice aged 12 (12\m=.\9\ m=+-\ 0\m=.\7%)and 18 (14\m=.\3\ m=+-\1\m=.\3%)months were significantly (P < 0\m=.\05) different from those of 2-month-old animals (10\m=.\5\ m=+-\ 0\m=.\7%).Significant differences were not observed in the cytogenetic studies for 6-, 12-, 18-and 25-month-old mice, although 2-month-old mice had a lower frequency (P < 0\m=.\05) of chromosomal aberrations compared to 12-and 18-month-old animals.
In addition to demonstrating the vapor pressure of liquids this amnmtus also effectively drmoniitrates the use ot a Utuhe manometer. students in introductory chemistry courses usuallv grasp the concept of pressure reasonably amell, but the i&of Rcolumn of mercury or water representinp. a given pressure is not as readily appreciated. Thus this demonstrntion apparatus opens an excellent oppurtunity to explain pressure measured in centimeters, millimeters, or inihes of mercury (or water)
Fischer 344 male rats were treated with cyclophosphamide (10 milligrams per kilogram of body weight) for 5 weeks and subsequently mated to females previously treated with saline or cyclophosphamide. The F1 progeny of the cyclophosphamide-treated males exhibited behavior deficits when compared to controls. These data could indicate a chemically induced genetic effect manifested by behavioral alterations.
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