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Aim: This study aimed to evaluate the serum ceruloplasmin (CP) level after non-surgical periodontal therapy in chronic periodontitis patients.Methods: A prospective controlled study was conducted on 80 subjects. The study populations were divided into 2 groups: group 1 included chronic periodontitis patients (study group, n = 40), and group 2 included periodontally healthy subjects (control group, n = 40). Blood sample and periodontal clinical parameters, including periodontal pocket depth, clinical attachment level and bleeding on probing, were performed at baseline for both groups. All of the patients with chronic periodontitis (study group) received meticulous scaling and root planing twice weekly for 2 weeks. Four weeks after treatment, the second blood sample and reevaluation of clinical periodontal parameters were done. Results:Baseline serum CP level was significantly higher in chronic periodontitis patients (study group) compared to healthy subjects (control group) (P < 0.001). Concerning the chronic periodontitis group, four weeks after non-surgical periodontal therapy, the mean value of serum CP concentration was significantly decreased (P < 0.001). Conclusion:Non-surgical periodontal therapy has a reducing effect on the serum CP level in chronic periodontitis patients.Serum CP level represents a potential biomarker indicator of the chronic periodontitis disease.

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The oral squamous cell carcinoma (OSCC) is the most frequent type of cancer within the head and neck region, and it is a significant cause of cancer morbidity and mortality with estimated 53,000 new cases annually in the United States. Early detection of OSCC increases the 5-year survival rate to 90%, whereas in later stages the survival rate decreases to about 30% (Ferlay et al., 2015;Siegel et al., 2019).Oral cancer is a multifactorial disease, and its risk factors vary among different populations. However, the most prominent risk factors are tobacco and heavy consumption of alcohol (LoConte et al., 2018). With the reduction of tobacco consumption in the United States, Human papillomavirus virus (HPV)-involvement in OSCC has increased, and it is assumed that HPV may replace tobacco as the main causative agent (Miller & Johnstone, 2001).HPVs are a double-stranded DNA virus that affects the skin as well as oral mucosa. HPV-16 is the most prevalent genotype

Background:Periodontal health has great impact on overall oral conditions which reflects subjects health. With the radical change that happened to human diet in the past several decades specially the wide spread of finely processed diet over the raw complex diet, it led to increase in several health problems which among them is the periodontal diseases. The periodontal therapy had been relaying on oral hygiene where a lot of researches where implied on adjunctive products which it could promote tissue healing after scaling and root planning as the prim treatment for such conditions. Many of these products showed side effects on long term use. So, apparently the search of a safe product that fulfil this rule would be a wise choice. Aim: The present study was designed to investigate the clinical and microbiological effectiveness of subgingivally delivered mango extract loaded on oxidized paper points (OPP) as an adjunct to scaling and root planing (SRP) in the treatment of periodontitis. Patients and methods:Thirty subjects with periodontal pockets were selected. For each, one site was randomly assigned to receive SRP+mangiferin, SRP+chlorhexidine and a third site received SRP only. The evaluated clinical outcomes were plaque index, gingival index, sulcus bleeding index, and PPD at baseline, two weeks and one month. Microbial analysis was done to estimate the count of aerobic and anerobic counts and also to assess antimicrobial activities of mangiferin against Porphyromonasgingivalis and Prevotella intermedia as compared to well-known antibiotics. Results: There was an intra-group significant reduction in each of the all clinical indices after 2 and 4 weeks of treatment. There were significant differences in each of PI, GI, and SBI between the negative control group and each of the study and positive control groups. There were no significant differences in these indices between the test and positive control groups. PPD showed no significant inter-group differences at any time points. There was intra-group significant reduction in each of the aerobic and anaerobic bacterial counts. There were no significant inter-group differences in these bacterial counts. Comparison in the inhibition zone of mangiferin and chlorhexidine showed that there was a significant difference favoring the mangiferin against tested organisms. There were significant differences between mangiferin when its inhibition zone was compared to tested antibiotics. Conclusion:These results suggested that mangiferin could be used as a good adjuvant in periodontal therapy and this treatment might improve the clinical parameters and reduce the bacterial count as comparable to the gold standard chlorhexidine treatment.

Periodontal disease denotes a group of oral inflammatory infections. This infectious disease severity varies from minor and reversible gingiva inflammation (gingivitis) to chronic damage of CT. 1 This process causes separation of the gum tissues from the tooth, producing a periodontal pocket and bone loss, which causing tooth loosening. 2 Lipopolysaccharide (LPS) is a main compound present in the membrane of Gram negative bacteria. It has the ability to initiate immune responses by stimulating cells that reside in the periodontal tissues, leading to releasing of large numbers of inflammatory mediators including interleukins, chemokines and adhesion molecules. 3 After recognition and presentation of microbes to the appropriate cells, cytokines of the innate response, including tumor necrosis factor alpha (TNF-α), interleukin-1beta (IL-1β) and interleukin-6 (IL-6), are the first to appear in the periodontal disease pathogenesis pathways. 4 IL-1β and IL-6 are signature innate cytokines and have been characteristically associated with inflammatory cell migration and osteoclastogenesis. 5

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