Biological effect of the nanocrystalline calcium sulfate bone graft in the periodontal regeneration

Mohammed, Abdulkarem A.; Elsherbini, Amira M.; Ibrahim, Fatma R.; El-Meadawy, Samah M.; Youssef, Jilan M.

doi:10.1016/j.jobcr.2020.10.012

Cited by 8 publications

(5 citation statements)

References 25 publications

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“…Periodontitis is a chronic inflammatory disease caused by the interaction between plaque biofilms and the host reaction, and its main clinical manifestations include gingival hemorrhage, periodontal pocket formation, alveolar bone resorption and tooth loss 1–5 . At present, the treatment of periodontitis is mainly nonsurgical, such as curettage or root planning, in order to control periodontal bacteria and plaque biofilms 6 .…”

Section: Introductionmentioning

confidence: 99%

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The improvement of periodontal tissue regeneration using a 3D‐printed carbon nanotube/chitosan/sodium alginate composite scaffold

Suo

Wang

et al. 2022

J Biomed Mater Res

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Periodontal disease is a common disease in the oral field, and many researchers are studying periodontal disease and try to find some biological scaffold materials to make periodontal tissue regenerative. In this study, we attempted to construct a carbon nanotube/chitosan/sodium alginate (CNT/CS/AL) ternary composite hydrogel and then prepare porous scaffold by 3D printing technology. Subsequently, characterizing the materials and testing the mechanical properties of the scaffold. Additionally, its effect on the proliferation of human periodontal ligament cells (hPDLCs) and its antibacterial effect on Porphyromonas gingivalis were detected. We found that CNT/CS/AL porous composite scaffolds with uniform pores could be successfully prepared. Moreover, with increasing CNT concentration, the degradation rate and the swelling degree of scaffold showed a downward trend. The compressive strength test indicated the elastic modulus of composite scaffolds ranged from 18 to 80 kPa, and 1% CNT/CS/AL group had the highest quantitative value. Subsequently, cell experiments showed that the CNT/CS/AL scaffold had good biocompatibility and could promote the proliferation of hPDLCs. Among 0.1%-1% CNT/CS/AL groups, the biocompatibility of 0.5% CNT/CS/AL scaffold performed best. Meanwhile, in vitro antibacterial experiments showed that the CNT/CS/AL scaffold had a certain bacteriostatic effect on P. gingivalis. When the concentration of CNT was more than 0.5%, the antimicrobial activity of composite scaffold was significantly promoted, and about 30% bacteria were inactivated. In conclusion, this 3D-printed CNT/CS/AL composite scaffold, with good material properties, biocompatibility and bacteriostatic activity, may be used for periodontal tissue regeneration, providing a new avenue for the treatment of periodontal disease.

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Section: Introductionmentioning

confidence: 99%

“…formation, alveolar bone resorption and tooth loss. [1][2][3][4][5] At present, the treatment of periodontitis is mainly nonsurgical, such as curettage or root planning, in order to control periodontal bacteria and plaque biofilms. 6 However, for severe periodontitis, periodontal surgery is required.…”

mentioning

confidence: 99%

The improvement of periodontal tissue regeneration using a 3D‐printed carbon nanotube/chitosan/sodium alginate composite scaffold

Suo

Wang

et al. 2022

J Biomed Mater Res

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“…Micro- and nanoformulated crystalline forms of calcium sulfate were attempted for use as a possible treatment for intrabony defects. The authors concluded that nanocrystalline calcium sulfate presented significantly enhanced periodontal regeneration compared to the microcrystalline form [ 32 ].…”

Section: Calcium Phosphate Biomaterialsmentioning

confidence: 99%

Role of Biomaterials Used for Periodontal Tissue Regeneration—A Concise Evidence-Based Review

Varghese

Rajagopal

2022

Polymers

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Periodontal infections are noncommunicable chronic inflammatory diseases of multifactorial origin that can induce destruction of both soft and hard tissues of the periodontium. The standard remedial modalities for periodontal regeneration include nonsurgical followed by surgical therapy with the adjunctive use of various biomaterials to achieve restoration of the lost tissues. Lately, there has been substantial development in the field of biomaterial, which includes the sole or combined use of osseous grafts, barrier membranes, growth factors and autogenic substitutes to achieve tissue and bone regeneration. Of these, bone replacement grafts have been widely explored for their osteogenic potential with varied outcomes. Osseous grafts are derived from either human, bovine or synthetic sources. Though the biologic response from autogenic biomaterials may be better, the use of bone replacement synthetic substitutes could be practical for clinical practice. This comprehensive review focuses initially on bone graft replacement substitutes, namely ceramic-based (calcium phosphate derivatives, bioactive glass) and autologous platelet concentrates, which assist in alveolar bone regeneration. Further literature compilations emphasize the innovations of biomaterials used as bone substitutes, barrier membranes and complex scaffold fabrication techniques that can mimic the histologically vital tissues required for the regeneration of periodontal apparatus.

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“…Calcium sulfate, a ceramic material, is widely used for various applications. It has been used as a binder material for building construction [1], bone graft material [2], periodontal disease treatment [3], endodontic lesions [4], alveolar bone loss [5], maxillary sinus augmentation [6], filler for plastic [7] and rubber [8], coating [9], desiccant [10], coagulant [11], catalyst [12], and bleaching agent [13]. Four calcium sulfate forms have been observed and previously reported: calcium sulfate dihydrate (CaSO 4 •2H 2 O, gypsum) [13], α-and β-calcium sulfate hemihydrate (CaSO 4 •0.5H 2 O, bassanite) [14], and calcium sulfate anhydrous (CaSO 4 , anhydrite) [15].…”

Section: Introductionmentioning

confidence: 99%

Sustainable Production and Physicochemical Characteristics of Calcium Sulfate Dihydrate Prepared from Waste Eggshells

Seesanong,

Seangarun,

Boonchom

et al. 2024

Crystals

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Gypsum products (calcium sulfate dihydrate, CaSO4·2H2O) were synthesized through an eco-friendly and low-cost process by two different renewable calcium carbonate sources (CaCO3), hen and duck eggshell wastes, with product yields obtained of 84.73 and 87.74%, respectively. The X-ray fluorescence results indicated that calcium oxide (CaO) and sulfur trioxide (SO3) are the major elemental components of CaSO4·2H2O prepared from both calcium sources. The Fourier transform infrared results confirmed the vibrational characteristics of SO42− and H2O functional groups in the chemical structure of the prepared samples. The X-ray diffraction patterns of CaSO4·2H2O prepared from both calcium sources confirmed the sample’s crystal structure as well as the chemical formula, after comparing them to the standard powder diffraction file. The crystallite sizes of CaSO4·2H2O products were calculated from the experimental diffraction peak through the Scherrer equation and found to be 19–20 nm. The positive preferential growth (Pg) value highlighted the excellent stability of the synthesized CaSO4·2H2O. The scanning electron microscopic results showed the agglomeration particles of hen- and duck-CaCO3 raw agents, whereas plate-like particles were observed for hen- and duck-CaSO4·2H2O products but the particle sizes were different.

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Biological effect of the nanocrystalline calcium sulfate bone graft in the periodontal regeneration

Cited by 8 publications

References 25 publications

The improvement of periodontal tissue regeneration using a 3D‐printed carbon nanotube/chitosan/sodium alginate composite scaffold

The improvement of periodontal tissue regeneration using a 3D‐printed carbon nanotube/chitosan/sodium alginate composite scaffold

Role of Biomaterials Used for Periodontal Tissue Regeneration—A Concise Evidence-Based Review

Sustainable Production and Physicochemical Characteristics of Calcium Sulfate Dihydrate Prepared from Waste Eggshells

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