Developing environmentally friendly lead-free dielectric ceramics with ultrahigh energy storage performance is fundamental to next-generation high-power capacitors but challenging as well. Herein, a record-breaking ultrahigh energy efficiency η of 97.8%...

Abundant evidence has illustrated that long non-coding RNA (lncRNA) plays a vital role in the regulation of tumor development and progression. Most lncRNAs have been proven to have biological and clinical significance in acute myeloid leukemia (AML), but further investigation remains necessary. In this study, we investigated lncRNA NR-104098 in AML and its specific mechanism. The microarray analysis was performed on NB4 cells. Based on the related analysis results, we identified that lncRNA NR-104098 is a suppressor gene that is significantly upregulated in AML cells. LncRNA NR-104098 could inhibit proliferation and induce differentiation in AML cells in vitro and also play main role in the mouse xenografts. Mechanically, it was confirmed that lncRNA NR-104098 may effectively inhibit EZH2 transcription by directly binding to E2F1 and recruiting E2F1 to the EZH2 promoter. In addition, ATPR can significantly increase the expression of lncRNA NR-104098, whereas knocking down NR104098 can inhibit the inhibitory effect of ATPR on the proliferation and induction differentiation of AML cells. Taken together, these results lead to deeper insight into the mechanism of ATPR-induced AML differentiation and prevent proliferation by inhibiting EZH2 on the transcriptional level.

Relaxor antiferroelectric (AFE) ceramic capacitors have drawn growing attention in future advanced pulsed power devices for their superior energy storage performance. However, state of the art dielectric materials are restricted by desirable comprehensive energy-storage features, which have become a longstanding hurdle for actual capacitor applications. Here, we report that a large energy density W rec of 5.52 J/cm3, high efficiency η of 83.3% at 560 kV/cm, high power density P D of 114.8 MW/cm3, ultrafast discharge rate t 0.9 of 45 ns, and remarkable stability against temperature (30–140 °C)/frequency (5–200 Hz)/cycles (1–105) are simultaneously achieved in 0.7 NaNbO3-0.3 CaTiO3 relaxor AFE ceramics via the synergy of stabilized AFE R phase and domain engineering in combination with breakdown strength enhancement. The structural origin for these achievements is disclosed by probing the in situ microstructure evolution by means of the first-order reversal curve method, piezoelectric force microscopy, and Raman spectroscopy. The highly dynamic polar nanoregions and stabilized AFE R phase synergistically generate a linear-like and highly stable polarization field response over a wide temperature and field scope with concurrently improved energy density and efficiency. This work offers a new solution for designing high-performance next-generation pulsed power capacitors.

The development of high‐performance lead‐free dielectric ceramic capacitors is essential in the field of advanced electronics and electrical power systems. A huge challenge, however, is how to simultaneously realize large recoverable energy density (Wrec), ultrahigh efficiency (η), and satisfactory temperature stability to effectuate next‐generation high/pulsed power capacitors applications. Here, a strategy of utilizing nanoscale polarization heterogeneous regions is demonstrated for high‐performance dielectric capacitors, showing comprehensive properties of large Wrec (≈6.39 J cm−3) and ultrahigh η (≈94.4%) at 700 kV cm−1 accompanied by excellent thermal endurance (20–160 °C), frequency stability (5–200 Hz), cycling reliability (1–105 cycles) at 500 kV cm−1, and superior charging‐discharging performance (discharge rate t0.9 ≈ 28.4 ns, power density PD ≈161.3 MW cm−3). The observations reveal that constructing the polarization heterogeneous regions in a linear dielectric to form novel relaxor ferroelectrics produces favorable microstructural characters, including extremely small polar nanoregions with high dynamics and multiphase coexistence and stable local structure symmetry, which enables large breakdown strength and ultralow polarization switching hysteresis, hence synergistically contributing to high‐efficient capacitive energy storage. This study thus opens up a novel strategy to design lead‐free dielectrics with comprehensive high‐efficient energy storage performance for advanced pulsed power capacitors applications.