A two-step chemical approach to synthesize high quality Fe 3 O 4 nanodisc is reported. The magnetic hyperthermia properties of the nanodisc and isotropic nanoparticles are investigated systematically. The results suggest that the nanodisc shows much higher specifi c absorption rate (SAR) than isotropic nanoparticles. This is attributed to the parallel alignment of nanodisc with respect to the alternating current magnetic fi eld, which is confi rmed by good agreement between experimental results and micromagnetic simulation. It is found that such parallel alignment could enhance the SAR value by a factor of ≈2 with respect to the randomly oriented case. The above results indicate that the nanodisc provides an excellent thermal seed for magnetic hyperthermia. This study sheds the light on the magnetic hyperthermia mechanism of magnetic nanodisc and it also opens the window to explore high effi ciency thermal seeds by controlling the orientation of magnetic nanostructures.
Octahedral Fe3O4 nanoparticles show a wide size range for high SAR values to be used as an excellent thermal seed for magnetic hyperthermia cancer treatment.
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