Ar egio-and stereoselective method for the synthesiso f( E)-a,b-unsaturated carbonyls has been developed via as ilver-catalyzedt andem epoxide rearrangement/intermolecular carbonyl-heteroalkyne metathesis.V arioush eteroalkynes including ynol ethers,y namides,a nd thioalkynes work well for this transformation, leading to the production of (E)-a,b-unsaturated esters,a mides,a nd thioesters in moderate to excellent yields with good functional group compatibility.I tr epresents one of the rare examples of regio-ands tereoselective intermolecular alkyne-carbonyl metathesis(ACM).
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.